局部外用酞丁安软膏后皮内浓度测定  

Intracutaneous Concentration Determination of Ftibamzone Oinment after Topical Administration

作　　者：吴黎莉[1] 陈沄[1] 隗慧林[1] 徐兰芳[1] 佘晓东[1] 沈珑瑛 潘显道 

机构地区：[1]中国医学科学院皮肤病研究所,南京210042 [2]北京协和药厂,102600

出　　处：《医学研究杂志》2012年第2期144-146,共3页Journal of Medical Research

摘　　要：目的测定试验动物皮肤给药后的皮内药物浓度,观察受试制剂的经皮渗透及进入皮肤的药物水平。方法试验乳猪局部外用酞丁胺软膏后,采用匀浆法结合高效液相色谱测定皮内药物浓度。结果酞丁安软膏外用于皮肤后,有一定量的经皮吸收和渗透,但是吸收量相对较低。结论本试验结果可为酞丁安人体皮肤药代动力学研究提供参考。Objective To determine the intracutaneous concentration of Ftibamzone given percutaneously to test animals and investi- gate its perentaneous penetrability and the intracutaneous drug level. Methods An HPLC method combined with homogeneization was used to determine the intracutaneous concentration of Ftibamzone after topical administration. Results The percutaneous absorption and penetrability of Ftibamzone was relatively low. Conclusion The results of the test can give reference to the study of dermatopharmacoki- netics of Ftibamzone in human.

关 键 词：酞丁安软膏 匀浆法 皮内浓度 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]