辛伐他汀对高胆固醇血症患者大动脉僵硬度的影响  

Effect of simvastatin on the large artery stiffness in hyperlipidemia patients without coronary artery disease

作　　者：张素敏[1] 于婕[2] 王广[3] 曾辉[2] 毛节明[2] 

机构地区：[1]北京大学医学部医院内科,北京100191 [2]北京大学第三医院心内科,北京100191 [3]北京大学第三医院内分泌科,北京100191

出　　处：《中国临床药理学杂志》2012年第3期163-164,178,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(30770873);中华医学会临床医学科研专项资金资助项目(07060590067);北京大学第三医院中青年骨干基金资助项目(78441-01)

摘　　要：目的观察辛伐他汀(降血脂药)对未合并冠心病的高胆固醇血症患者动脉僵硬度的影响。方法 51例高胆固醇血症患者应用辛伐他汀20 mg.d-1治疗12周,分别在0,12周测定患者的代谢指标、肱踝脉搏波传导速度(baPWV)。结果辛伐他汀治疗后,患者血浆总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平均明显降低((P<0.01,P<0.05);与治疗前相比,双侧baPWV水平均显著降低(双侧均P<0.01)。结论辛伐他汀可改善无明确冠心病的高胆固醇血症患者动脉血管硬化程度。Objective To investigate the effect of simvastatin on large artery stiffness in hyperlipidemia patients without coronary artery disease.Methods Fifty-one hyperlipidemia patients were treated with simvastatin（20 mg·d^-1）for 12 weeks.To evaluate the effect of atherosclerosis through simvastatin treatment.Metabolic index was collected by detecting the pulse wave velocity（PWV） of ankle brachial before and after therapy.Results Total cholesterol（TC） in plasma of patients was decreased dramatically after simvastatin treatment（P0.01）.Low density lipoprotein cholesterol（LDL-C） levels were obviously reduced（P0.05）.Bilateral baPWV levels were decreased significantly after treatment（P0.01）.Conclusion Atherosclerosis was improved by simvastatin treatment in hyperlipidemia patients without coronary artery disease.

关 键 词：高胆固醇血症 辛伐他汀 脉搏波速度 

分 类 号：R589.2[医药卫生—内分泌]