Inhibiting effect of Astragalus polysaccharides on the functions of CD4＋CD25^highTreg cells in the tumor microenvironment of human hepatocellular carcinoma  

作　　者：LI Qiang BAO Jian-min LI Xiao-li ZHANG Ti SHEN Xiao-hong 

机构地区：[1]Department of Hepatobiliary Surgery, Cancer Hospital of TianjinMedical University, Tianjin 300060, China [2]School of Pharmaceutical Science and Technology, TianjinUniversity, Tianjin 300072, China [3]Central Laboratory, Tianjin Academy of Traditional ChineseMedicine, Tianjin 300120, China [4]Medical College of Nankai University, Tianjin 300071, China

出　　处：《Chinese Medical Journal》2012年第5期786-793,共8页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China

摘　　要：Background Astragalus polysaccharides （APS）, the main active extract from Astragalus membranaceus （a traditional Chinese medicinal herb）, is associated with a variety of immunomodulatory activities. The purpose of the present study was to examine the effect of APS on the function of Treg cells in the tumor microenvironment of human hepatocellular carcinoma （HCC） and to identify the pharmacologic mechanism of APS responsible for the anti-chemotactic activity in CD4＋CD25^highTreq cells in tumor site of HCC.Background Astragalus polysaccharides （APS）, the main active extract from Astragalus membranaceus （a traditional Chinese medicinal herb）, is associated with a variety of immunomodulatory activities. The purpose of the present study was to examine the effect of APS on the function of Treg cells in the tumor microenvironment of human hepatocellular carcinoma （HCC） and to identify the pharmacologic mechanism of APS responsible for the anti-chemotactic activity in CD4＋CD25^highTreq cells in tumor site of HCC.

关 键 词：Astragalus polysaccharides hepatocellular carcinoma regulatory T cells tumor microenvironment 

分 类 号：Q954.43[生物学—动物学] S858.315.3[农业科学—临床兽医学]