Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure  

作　　者：GUO Yong-fang ZHANG Xiao-xia LIU Yong DUAN Hong-yan JIE Bing-zhang WU Xue-si 

机构地区：[1]Department of Cardiology, Beijing Anzhen Hospital, CapitalMedical University, Beijing 100029, China [2]Laboratory of Apoptosis and Cancer Biology, National KeyLaboratory of Biomembrane and Membrane Biotechnology,Institute of Zoology, Chinese Academy of Sciences, Beijing100101, China

出　　处：《Chinese Medical Journal》2012年第5期807-814,共8页中华医学杂志（英文版）

摘　　要：Background Mitochondrial dysfunction plays a pivotal role in the progression of left ventricular （LV） remodeling and heart failure （HF）. Recombinant human neuregulin-1 （rhNRG-1） improves cardiac function in models of experimental HF and in clinical trials; however, its impact on mitochondrial function during chronic HF remains largely unknown. The purpose of this study was to investigate whether rhNRG-1 could attenuate the functional and structural changes that occur in cardiac mitochondria in a rat model of HF induced by myocardial infarction.Background Mitochondrial dysfunction plays a pivotal role in the progression of left ventricular （LV） remodeling and heart failure （HF）. Recombinant human neuregulin-1 （rhNRG-1） improves cardiac function in models of experimental HF and in clinical trials; however, its impact on mitochondrial function during chronic HF remains largely unknown. The purpose of this study was to investigate whether rhNRG-1 could attenuate the functional and structural changes that occur in cardiac mitochondria in a rat model of HF induced by myocardial infarction.

关 键 词：NEUREGULIN-1 heart failure MITOCHONDRIA CARDIOPROTECTION 

分 类 号：Q463[生物学—生理学] S858.966[农业科学—临床兽医学]