Functional MRI study of mild Alzheimer＇s disease using amplitude of low frequency fluctuation analysis  

作　　者：XI Qian ZHAO Xiao-hu WANG Pei-jun GUO Qi-hao YAN Chao-gan HE Yong 

机构地区：[1]Department of Radiology, Tongji Hospital of Tongji University,Shanghai 200065, China [2]Department of Neurology, Huashan Hospital of Fudan University,Shanghai 200040, China [3]State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University, Beijing 100875, China

出　　处：《Chinese Medical Journal》2012年第5期858-862,共5页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China （No. 30970818）, and the National High-Tech Research and Development Program of China （No. 2008AA02Z302）.

摘　　要：Background Previous studies have shown that the functional brain activity in the resting state is impaired in Alzheimer＇s disease （AD） patients. However, most studies focused on the relationship between different brain areas, rather than the amplitude or strength of the regional brain activity. The purpose of this study was to explore the functional brain changes in AD patients by measuring the amplitude of the blood oxygenation level dependent （BOLD） functional MRI （fMRI） signals.Background Previous studies have shown that the functional brain activity in the resting state is impaired in Alzheimer＇s disease （AD） patients. However, most studies focused on the relationship between different brain areas, rather than the amplitude or strength of the regional brain activity. The purpose of this study was to explore the functional brain changes in AD patients by measuring the amplitude of the blood oxygenation level dependent （BOLD） functional MRI （fMRI） signals.

关 键 词：Alzheimer＇s disease resting-state functional MRI amplitude of low frequency fluctuation 

分 类 号：Q426[生物学—神经生物学] TQ463.54[生物学—生理学]