Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations  

作　　者：HAN Jing ZHANG Tian-ou XIAO Wen-hua CHANG Cui-qing AI Hua 

机构地区：[1]Department of Nutrition and Biochemistry, Institute of SportsMedicine Peking University Third Hospital,Beijing 100191, China [2]Department ofEndocrinology, Peking University Third Hospital,Beijing 100191, China

出　　处：《Chinese Medical Journal》2012年第5期874-881,共8页中华医学杂志（英文版）

基　　金：This study was partially supported by grants from the National Natural Science Foundation of China （No. 30270636 and 30671015）.

摘　　要：Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.Background Visfatin, a visceral fat-derived adipocytokine, plays a significant physiological function in lipid metabolism. However, the precise function of visfatin and its regulation by thyroid hormones are still unknown. This study observed the plasma visfatin concentrations in subjects with hyperthyroidism and hypothyroidism in vivo, and investigated the possible reaulation mechanism between visfatin and tri-iodothvronine （T3） in vitro as a further interpretation.

关 键 词：thyroid dysfunction ADIPOCYTOKINES thyroid hormone 3T3-L1 cells 

分 类 号：Q572[生物学—生物化学] TQ464.9[化学工程—制药化工]