Prevalence and characterization of plasmid-mediated blaESBL with their genetic environment in Escherichia coli and Klebsiella pneumoniae in patients with pneumonia  

作　　者：WANG Xiao-rong CHEN Ji-chao KANG Yu JIANG Ning AN Shu-chang GAO Zhan-cheng 

机构地区：[1]Department of Respiratory ＆ Critical Care Medicine, PekingUniversity People＇s Hospital, Beijing 100044, China [2]Department of Respiratory Medicine, Central Hospital of ChinaAerospace Corporation, Beijing 100049, China [3]Beijing Institute of Genomics, Chinese Academy of Sciences,Beijing 100029, China

出　　处：《Chinese Medical Journal》2012年第5期894-900,共7页中华医学杂志（英文版）

摘　　要：Background The extended spectrum 13-1actamase （ESBL）-producing Escherichia coil （E. coh） and Klebsiella pneumoniae （K. pneumoniae） are the major pathogens causing pneumonia and have a significant impact on the clinical course. Limited data exist on molecular characterization of ESBL-producing E. coli and K. pneumoniae that cause pneumonia. The aim of this study was to investigate the comprehensive multilevel characteristics of E. coil and K. pneumoniae causing pneumonia in China for the first time.Background The extended spectrum 13-1actamase （ESBL）-producing Escherichia coil （E. coh） and Klebsiella pneumoniae （K. pneumoniae） are the major pathogens causing pneumonia and have a significant impact on the clinical course. Limited data exist on molecular characterization of ESBL-producing E. coli and K. pneumoniae that cause pneumonia. The aim of this study was to investigate the comprehensive multilevel characteristics of E. coil and K. pneumoniae causing pneumonia in China for the first time.

关 键 词：mechanism of resistance promoter CTX-M SHV  gene silence plasmid incompatibility group 

分 类 号：Q556[生物学—生物化学] Q78