痛风与脂代谢紊乱及肥胖的关系  

Correlation of gout with lipid metabolic disorder and obesity

作　　者：王荟[1] 吴秀英[1] 李长贵[1] 

机构地区：[1]青岛大学医学院附属医院,山东青岛266003

出　　处：《山东医药》2012年第5期10-12,共3页Shandong Medical Journal

基　　金：科技部973计划前期研究专项(2010CB534902);国家自然科学基金(30570890;30871192)

摘　　要：目的探讨男性家系及散发痛风患者的临床、生化特征及痛风与脂代谢紊乱、肥胖的关系。方法选择初诊男性家系痛风354例(家系组)和初诊男性散发痛风1 347例(散发组),分析两组年龄、身高、体质量、体质量指数、腰围、臀围、腰臀比等临床特征,检测其甘油三酯、胆固醇、血尿酸等生化指标。同时,观察两组非诺贝特治疗6个月、1年患者生化指标的变化。结果初诊家系组与散发组中,超重与肥胖、腹型肥胖、高甘油三酯、高胆固醇、高尿酸指标均与痛风相关;家系组与散发组比较,腹型肥胖指标差异有统计学意义(P<0.05)。两组非诺贝特治疗6个月、1年后,甘油三酯、胆固醇、血尿酸与治疗前比较,差异有统计学意义(P均<0.05)。随着用药时间的延长,治疗作用更明显。结论不论家系或散发痛风患者,均易合并肥胖、脂代谢紊乱;治疗痛风的同时,应关注患者血脂变化。Objective To analyze the clinical and biochemical characteristics of male cases with familial and sporadic gout treated in gout clinical medical center of Shan Dong province from 2008 to 2011 retrospectively for further studying the relationship between gout, lipid metabolic disorder and obesity. Methods The clinical and biochemical characteristics （age, height,weight, BMI, waist circumference, hip circumference, WHR, triglyceride, cholesterol, serum uric acid） of 354 male first-visit cases with familial gout, 1 347 male first-visit cases with sporadic gout, were compared and analyzed. The re-visit patients received regular recheck-up and were treated regularly in gout clinical medical center 6 months and 1 year after first diagnosed. Results Overweight and obesity, abdominal obesity, triglyceride elevation, cholesterol eleva- tion, hyperuricemia were all related with gout. The difference of above indexes between the patients of these two groups had no statistical significance, except abdominal obesity. When treated with lipanthyl for 6 months and 1 year, the difference of triglyceride, cholesterol, serum uric acid between all the patients of these two groups had statistical significance （P 〈 0.05） as compared with those before treatment. The therapeutic effects became more and more obvious as the time was get- ting longer. Compared with the effect of lipanthy＇ s decreasing cholesterol, the difference of lipanthy＇ s decreasing triglyceride was more significant in male patients with sporadic gout. Conclusion No matter the cases with familial gout or with sporadic gout, all the patients were inclined to complicate with obesity or lipid metabolic disorder. So at the same time of treating gout, we should also pay attention to the change of blood lipid.

关 键 词：痛风 脂代谢紊乱 肥胖症 

分 类 号：R589.7[医药卫生—内分泌] R589.2[医药卫生—内科学]