基质金属蛋白酶与主动脉夹层发病关系的研究进展  

Progress of Research in the Relationship between Matrix Metalloproteinase and the Pathology of Aortic Dissection

作　　者：裴华伟[1] 常谦[1] 

机构地区：[1]北京协和医学院中国医学科学院阜外心血管病医院血管外科中心,北京100037

出　　处：《中国分子心脏病学杂志》2012年第1期57-60,共4页Molecular Cardiology of China

摘　　要：主动脉夹层是一种严重威胁人类生命健康的心血管疾病,常伴有较高的死亡率及并发症率,但目前其发病原因仍不明确。文献报道主动脉夹层的发病与主动脉中层退行变有关,而基质金属蛋白酶(Matrix Metalloproteinase,MMP)在细胞外基质代谢过程中发挥重要作用,其活性或含量增加可引起主动脉中层结构蛋白的过度降解,参与主动脉中层退行变,初步表明基质金属蛋白酶在主动脉夹层发病过程中可能发挥重要作用。本文就近年来有关MMP与主动脉夹层发病关系的研究进行综述。Aortic dissection is a serious life-threatening cardiovascular disease, often accompanied by high mortality and mobidity, but its etiology remains unclear.. Dissection is associated with degeneration of the aortic media, and matrix metalloproteinases （MMPs） play an important role in the metabolic processes of extracellular matrix. Several studies have shown increased expression and activation of MMPs can cause excessive degradation of the structural proteins and degeneration of aortic media, suggesting that MMPs may play a major role in aortic dissectiola. This article reviews the recent literature of the MMPs in the pathogenesis of aortic dissection.

关 键 词：主动脉夹层 基质金属蛋白酶 基质胶原蛋白 弹性蛋白 

分 类 号：R543.1[医药卫生—心血管疾病]