病毒感染与细胞核转录因子-κB信号转导的相互作用关系  

Interaction between Virus Infection and NF-kappaB Signal Transduction

作　　者：黄慧[1] 严玉霖[1,2] 高洪[1] 高利波[1] 赵汝[1] 陈玲[1] 蒋欢[1] 陈冈[1] 

机构地区：[1]云南农业大学动物科学技术学院,云南昆明650201 [2]中国农业科学院家畜疫病病原生物学国家重点实验室,甘肃兰州730046

出　　处：《中国畜牧兽医》2012年第3期134-136,共3页China Animal Husbandry & Veterinary Medicine

基　　金：云南省高校科技创新团队支持计划资助项目(云教科[2011]4号);云南省现代农业生猪产业技术体系建设(云财农[2010]119号);云南省高端科技人才引进计划项目(2009CI125)

摘　　要：自发现细胞核转录因子-κB(NF-κB)以来,人们对其分子生物学特征、作用机制及其与疾病的关系作了广泛的研究。近年来的研究结果发现,NF-κB在病毒感染与疾病发生的过程中发挥着重要作用。病毒感染真核细胞时能诱导NF-κB从细胞质转移到细胞核,从而诱导一些炎性基因转录产生大量炎性因子引起炎症反应,或阻碍细胞凋亡促进其自身在宿主细胞内的复制,或促进某些原癌基因的表达使细胞癌化等。不同病毒感染机体时,都会通过对NF-κB信号转导的影响,改变机体的某些性状,导致疾病的产生。目前已发现应激刺激、细菌脂多糖、病毒、氧自由基等很多因素能激活NF-κB,而后通过NF-κB信号转导通路的桥接作用影响机体的新陈代谢,文章就病毒感染与细胞NF-κB信号转导的相互作用关系作一综述。Since we found NF-kappaB,it has been studied widely about its molecular biology characteristics,function mechanism and the relationships with diseases.Recently many studies reveal that the NF-kappaB plays an important role in the process of virus infection and disease.The translocation of NF-kappaB from the cytoplasm to the nucleus can be induced when virus infect eukaryotic cells,consequently or inducing transcription of some inflammatory gene to produce a lot of inflammatory factors,or blocking apoptosis and prolonging survival of the host cell to gain time for replication and increase viral progeny production,or promoting the expression of oncogene to make cells cancerization,and so on.Once virus infection,body properties will be changed through NF-kappaB signal transduction and diseases will appear soon.Many fators,which has been found at present,such as stress stimulator,LPS,virus,oxygen free radical and so on,are all able to activate the NF-kappaB and then affect the body＇s metabolism through NF-kappaB signal pathway.In this paper,the interaction between virus infection and NF-kappaB signal transduction is reviewed.

关 键 词：病毒感染 核转录因子-ΚB 信号转导 

分 类 号：S855.3[农业科学—临床兽医学]