体外培养细胞端粒酶活性调控的研究进展  

Advances of Telomerase Activation Regulation in Cells Cultured in Vitro

作　　者：孙武胜[1] 王楠楠[1] 徐礼杰[1] 方南洙[1] 李钟淑[1] 李福俊[1] 

机构地区：[1]延边大学农学院动物科学系,吉林延吉133000

出　　处：《中国畜牧兽医》2012年第3期137-140,共4页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金项目(30860184);延边大学"211工程"三期建设项目

摘　　要：端粒酶可修复细胞分裂过程中不断丢失的端粒序列,从而维持端粒的长度,在动物细胞寿命的调控中起着很重要的作用。因此,通过调控细胞中端粒酶的活性来影响体外培养细胞的发育状况,是目前提高体外培养效率的有效方法之一。文章对调节细胞中端粒酶活性的研究进展作一综述。Telomerase is capable of maintaining telomere lengths by balancing out the gradual loss of telomeric sequences that occurs during cell division.It plays an important role in regulating life span of animal cells.In order to improve cell culture efficiency in vitro,a great deal of research has been attempted.And the way of increasing the activity of telomerase is considered to be one of the most effective approaches to improve cell culture efficiency.This article will make a brief summary of these recent achievements.

关 键 词：哺乳动物 卵母细胞 培养体系 端粒酶活性 调控 

分 类 号：S814.8[农业科学—畜牧学]