IL-23/IL-17轴在银屑病免疫发病机制中的作用  

The IL-23/IL-17 axis in the immunopathogenesis of psoriasis

作　　者：赵京霞[1] 王燕[1] 底婷婷[1] 刘欣[1] 李萍[1] 

机构地区：[1]北京市中医研究所,北京100010

出　　处：《基础医学与临床》2012年第4期453-456,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81072810);北京市科技计划重大课题(D08050703550901)

摘　　要：银屑病是一种以T淋巴细胞异常活化和浸润为主要特征的慢性炎性反应皮肤病。Th17细胞及IL-23/IL-17轴在银屑病的发病机制中可能处于关键地位,并成为新的治疗靶标。IL-23诱导Th17细胞分化增殖,分化成熟的Th17可以分泌IL-17、IL-21、IL-22等多种细胞因子,Th17类细胞因子在银屑病等多种自身免疫疾病和炎性疾病中起重要作用。Psoriasis is a chronic inflammatory skin disease characterized by abnormal activated T cells infiltration.Recently,Th17 cells and IL-23/ IL-17 axis has being recognized as a key player and potential therapeutic target in psoriasis.IL-23 is able to induce Th17 cell activation with production of pro-inflammatory cytokines such as IL-17A,IL-17F,IL-22.Th17-related cytokines play a functional role in psoriasis and other autoimmune diseases.

关 键 词：IL-23 TH17 IL-17 银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]