二甲双胍对高脂诱导胰岛素抵抗大鼠vaspinmRNA表达水平的影响  

The effect of metformin on expression of vaspin mRNA in insulin resistant rats induced by high-fat diet

作　　者：刘慧蔷[1] 裴丽娜[1] 都健[1] 杨晶[1] 张盈妍[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110001

出　　处：《中华内分泌代谢杂志》2012年第3期231-234,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：辽宁省科学技术计划项目（2009225029）;辽宁省教育厅科技项目（L2010597）

摘　　要：采用高脂喂养并利用清醒状态下正糖一高胰岛素钳夹技术评估胰岛素抵抗大鼠模型。胰岛素抵抗大鼠脂肪组织vaspin mRNA表达量明显低于对照组（P〈0．05），二甲双胍治疗后表达升高（P〈0．05），提示二甲双胍在改善大鼠胰岛素抵抗状态的同时能上调胰岛素抵抗大鼠内脏脂肪组织vaspinmRNA的表达。High-fat diet-induced＇insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique. Compared with the control group, the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet （P〈0. 05 ）, which was increased by metformin （P〈0. 05 ）. These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression.

关 键 词：胰岛素抵抗 VASPIN 二甲双胍 正常血糖-高胰岛素钳夹技术 大鼠 

分 类 号：R587.1[医药卫生—内分泌]