血清γ-谷氨酰转移酶与空腹血糖的相关性  

Relationship between serum γ-glutamyltransferase and fasting blood glucose

作　　者：丁扬[1] 马向华 沈捷[3] 张媛媛[1] 徐海凤[1] 桑谊荃[1] 杨涛 王知笑 龚磊[4] 

机构地区：[1]南京医科大学第一临床医学院,江苏省210029 [2]南京医科大学第一附属医院内分泌病科 [3]南京医科大学HLA实验室 [4]高邮市卫生局

出　　处：《江苏医药》2012年第6期660-662,共3页Jiangsu Medical Journal

基　　金：江苏省亚健康高危人群综合干预示范研究项目(BE2009613)

摘　　要：目的探讨血清γ-谷氨酰转移酶(GGT)与空腹血糖(FBG)的相关性。方法对江苏高邮地区人群分层随机抽样,纳入分析4248人,检测血清GGT、FBG及相关代谢指标;根据FBG水平分为A组2389人(FBG<5.6mmol/L)、B组1677人(5.6≤FBG≤6.9mmol/L)和C组182人(FBG≥7.0mmol/L)。结果 A、B、C三组GGT水平依次增高,男性高于女性(P<0.05)。多元逐步回归分析显示,GGT与FBG独立相关,女性较男性更显著。Logistic回归分析显示,第4四分位GGT水平与第1四分位相比,FBG升高(≥7.0mmol/L)的比值比(OR)(95%CI)值,男性为3.17(1.34,7.46),低于女性7.00(3.01,14.93)。结论 GGT是FBG升高的风险预测因子;女性FBG升高的风险高于相同GGT水平的男性。Objective To investigate the relationship between serum γ-glutamyltransferase（GGT） level and fasting blood glucose（FBG）. Methods A random,multi-stage cross-sectional study was conducted in Gaoyou,Jiangsu Province and a total of 4248 subjects was enrolled in the study. GGT,FBG and related metabolic indexes were detected.According to FBG levels,the subjects were divided into three groups of A（FBG5.6 mmol/L,n=2389）,B（5.6≤FBG≤ 6.9 mmol/L,n=1677） and C（FBG≥7.0 mmol/L,n=182）. Results GGT level increased in an order of group Agroup Bgroup C,which was much higer in men than that in women（P0.05）.Multivariate stepwise regression analysis showed that GGT was a significant risk factor for high FBG,which was more sensitive in women than that in men.Logistic analysis showed that compared with the first quartile of GGT level,the OR（95%CI） value on high FBG（≥7.0 mmol/L） for the fourth quartile was 3.17（1.34,7.46） in men,which was obviously lower than 7.00（3.01,14.93） in women. ConclusionGGT is a risk predictor of high FBG and the predicting value is greater for women than for men under the same GGT levels.

关 键 词：Γ-谷氨酰转移酶 空腹血糖 

分 类 号：R587[医药卫生—内分泌]