氯喹加伯喹、复方乙胺嘧啶加伯喹单剂抑制间日疟恶性疟原虫孢子增殖的效果  

EFFECT OF COMBINED USE OF CHLOROQUINE/PRIMAQUINE AND PYRIMETHAMINE/SULFAMETHOXINUM/PRIMAQUINE ON THE SPOROGONY OF PLASMODIUM VIVAX AND FALClPARUM IN ANOPHELES VECTORS

作　　者：李华宪[1] 黄国珍[1] 

机构地区：[1]云南省疟疾防治研究所

出　　处：《中国寄生虫病防治杂志》1990年第2期115-117,共3页Chinese Journal of Parasitic Disease Control

基　　金：云南省卫生厅科教处青年科学基金

摘　　要：本文观察了3例思茅的间日疟病人顿服氯喹(基质)600mg+伯喹(基质)22.5mg、2例勐腊的恶性疟病人顿服乙胺嘧啶70mg+周效磺胺1000mg+伯喹(基质)22.5mg 后,药物在蚊体内抑制疟原虫孢子增殖的效果。结果显示:服药后8h 内两种疟原虫在吸血蚊体内仍能进行孢子增殖;间日疟原虫配子体在24～96h 内转阴,服药后12h～10d 内中华按蚊未受感染;恶性疟原虫配子体在10d 内未转阴,服药后12h～9d 内大劣按蚊未受感染,其中1例于 d10复燃并使大劣按蚊重获感染。结果提示上述服药方法用于防止传染源境外输入时,对入境留宿的边民最好在蚊媒活动8h 以前给药。Three patients with vivax malaria from Simao and two patients with falciparum malaria from Mengla were treated orally with a combined dose of chloroquine 600mg/primaquine 22.5mg and pyrimethamine 70mg/sulfamethoxinum 1000mg/primaquine 22.5mg respectively,for observing the effects of the drugs in restraining sporogony of the parasites in Anopheles vectors.Thenumber of gametocytes in blood from the patients with vivax malaria was more than 100/μl and with falciparum malaria,70/μl. The results showed that the administration of these drugs did not restrain the sporogoay of P.vivax in An.sinensis and P.falciparum in An.dirus within 8 hours after treatment.The gametocyte clearance time of P.vivax was 24 or 96 hours,but An.sinensis could not be infected 12 hours later or in 10 days.The gametocyte of P. falciparum was not cleared as observed for 10 days,while it also could not cause the An.dirus to be infected. These results suggest that the time of medication should be 8 hours before contacting with Anopheles vectors when the method is used for preventing the import of the sources of infection.

关 键 词：疟原虫 配子体 孢子 增殖 抗疟药 

分 类 号：R978.61[医药卫生—药品]