不同病原菌感染脓毒症患者血浆血管生成素-2水平变化  

Plasma angiopoietin-2 levels in septic patients with different pathogen infection

作　　者：陈秋萍[1] 张媛莉[1] 姚华国[1] 邓烈华[1] 

机构地区：[1]广东医学院附属医院老年病科,广东湛江524001

出　　处：《中国现代医生》2012年第10期8-10,共3页China Modern Doctor

基　　金：广东省医学科研基金项目(A2009484)

摘　　要：目的探讨不同病原菌感染的脓毒症患者血浆血管生成素-2(angiopoietin-2,Ang-2)水平变化及其与病情严重程度的关系。方法将67例脓毒症患者分为深部真菌感染组(11例)、二重感染组(G-菌合并真菌感染,36例)和革兰阴性(G-)菌感染组(20例),另选取20例健康志愿者(10男10女)为对照组。67例脓毒症患者24 h内进行急性生理和慢性健康状况(APACHEⅡ)评分、序贯器官衰竭(SOFA)评分,同时采集血标本,检测血浆Ang-2水平并与对照组比较。结果脓毒症各组患者的APACHEⅡ评分和SOFA评分均明显高于正常对照组(P<0.01);与正常对照组相比较,脓毒症各组患者的血浆Ang-2水平均显著升高(P<0.05),而脓毒症各组患者之间的血浆Ang-2水平比较差异无统计学意义(P>0.05)。各组患者血浆Ang-2水平与APACHEⅡ评分及SOFA评分均呈正相关(r=0.599,P<0.05;r=0.723,P<0.05);多元线性回归分析显示Ang-2与APACHEⅡ评分及SOFA评分均呈显著独立相关(β=0.468,P<0.05;β=0.626,P<0.001)。结论脓毒症患者的血浆Ang-2水平显著升高,并与APACHEⅡ评分及SOFA评分均呈正相关,是影响脓毒症患者病情严重程度的独立危险因素。Objective To investigate the plasma levels of angiopoietin-2 （Ang-2） in septic patients with different pathogen infection, and their correlations with the severity of septic patients. Methods The septic patients were divided into three subgroups which were the deep fungal infection group （n = 11）, the double infection group caused by fungi and Gram-neg- ative bacteria （n = 36） and the Gram-negative bacteria infection group （n = 20）, Ten male and ten female healthy volun- teers were selected for the control group. The clinical data including the acute physiology and chronic health conditions （APACHE） Ⅱ score and sequential organ failure （SOFA） score were collected and recorded. Blood samples were collected. Plasma Ang-2 was detected and statistical analyzed. Results APACHE Ⅱ score and SOFA score were significantly higher in patients of septic groups than in healthy control subjects （P〈 0.01）. Plasma Ang-2 levels were significantly higher in three septic groups than in healthy control group （P 〈 0.05）. There were no significant differences of the plasma levels of Ang-2 among three septic groups （P 〉 0.05）. The plasma Ang-2 levels and score of APACHE Ⅱ and SOFA were signifi- cant correlation （r = 0.599, P 〈 0.05; r = 0.723, P 〈 0.05, respectively）. Multiple linear regression analysis showed that plasma Ang-2 levels were significantly independently correlated with the score of APACHE Ⅱ and SOFA （β = 0.468, P 〈 0.05;β = 0.626, P 〈0.001, respectively）. Conclusion Ang-2 levels were increased significantly and correlated indepen- dently with score of APACHE Ⅱ and SOFA in septic patients. Ang-2 level is an independent risk factor associated with the severity of septic patients.

关 键 词：脓毒症:血管生成素-2 

分 类 号：R631[医药卫生—外科学]