神经支配与拔牙窝的骨愈合  

Effect of innervation on bone healing after tooth extraction

作　　者：林海[3] 王承勇[1,2] 王锦[3] 卢萌[1,2] 陈伟辉[1,2,3] 

机构地区：[1]福建医科大学牙颌面畸形防治研究室,福建省福州市350001 [2]福建医科大学附属协和医院口腔颌面外科,福建省福州市350001 [3]福建医科大学口腔医学院,福建省福州市350001

出　　处：《中国组织工程研究》2012年第7期1141-1144,共4页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金资助项目(31070838)~~

摘　　要：背景:拔牙窝的新骨形成与骨量保持受体内外多种因素调控,神经系统通过介导成骨细胞和破骨细胞调节骨代谢。目的:观察神经支配对拔牙窝骨愈合的调节作用,探讨神经支配与拔牙窝骨愈合的相互关系。方法:切除犬一侧下牙槽神经建立失神经支配动物模型,以未切除侧为对照,拔除失神经支配侧和正常侧前磨牙,放射影像学方法检测术后2,4,8,12周拔牙窝新骨形成和骨量保持。结果与结论:失神经支配组拔牙窝骨缺损区牙槽嵴高度、宽度和CT值明显低于对照组(P<0.01);实验组拔牙窝唇颊侧牙槽嵴高度明显低于对照组(P<0.05或0.01),舌侧牙槽嵴高度差明显高于对照组(P<0.05或0.01)。提示失下牙槽神经支配影响拔牙窝的新骨形成及骨量保持,二者之间存在密切相关性。BACKGROUND：New bone formation and bone mass maintenance in extraction sockets is regulated by many factors in vivo.Nervous system regulates the bone metabolism by mediating osteoblasts and osteoclasts.OBJECTIVE：To study the effect of innervation on bone healing and to probe the relationgship between innervation and bone healing in extraction sockets.METHODS：Dog unilateral inferior nerve was sectioned to establish an animal denervation model.The normal side was used as comparison.After model construction,the premolar of denervated side and normal side were extracted.Imagelogy method was used to test the bone formation and bone mass maintenance in the extraction sockets in the 2nd,4th,8th and 12th weeks.RESULTS AND CONCLUSION：The height,width and CT values in extraction socket bone defect sites of the experiment group was significantly lower than that of the control group（P 0.01）.The height of the buccal alveolar ridge in experiment group was significantly lower than that in the control group（P 0.05 or P 0.01）.The height of the lingual alveolar ridge of experiment group was significantly higher than that of the control group（P 0.05 or P 0.01）.These findings indicate that innervations play an important role in the regulation of bone formation and bone mass maintenance in the extraction sockets;there is a close relationship between them.

关 键 词：神经支配 失神经支配 拔牙窝 骨愈合 下牙槽神经 

分 类 号：R318[医药卫生—生物医学工程]