局部应用阿伦膦酸钠对非负荷期种植体骨结合影响的X射线观察  

Effect of topical application of alendronate on implant osseointegration in non-load period:A X-ray observation

作　　者：纪林林[1] 柳忠豪 周文娟 许胜 

机构地区：[1]滨州医学院研究生院,山东省烟台市264003 [2]烟台市口腔医院,山东省烟台市264008

出　　处：《中国组织工程研究》2012年第9期1573-1576,共4页Chinese Journal of Tissue Engineering Research

基　　金：山东省自然科学基金项目计划(Y2008C43);局部应用阿伦膦酸钠对非负荷期种植体骨结合的影响~~

摘　　要：背景:阿伦膦酸钠作为第3代二膦酸盐,具有很强的抑制骨吸收的能力。目的:研究阿伦膦酸钠对非负荷期种植体周围骨结合的影响。方法:取健康成年Beagle犬6只,随机等分为实验组和对照组,选取每犬的双侧下颌第二、四前磨牙共计24牙位,于实验第1,29,43,50天分别行即刻种植手术。实验组于种植体周围局部注射阿伦膦酸钠,对照组注射生理盐水,每周2次。结果与结论:于实验第57天进行X射线显示种植体骨结合情况良好,实验组2周时即可见到种植体周围骨小梁的形成,明显早于对照组。提示阿伦膦酸钠可促进种植体周围骨组织中骨小梁的早期形成,从而影响种植体周围骨改建,提高非负荷期种植体周围骨结合。BACKGROUND：As the third-generation of bisphosphonates,alendronate has a strong ability in inhibiting bone resorption.OBJECTIVE：To study the effect of alendronate on non-load period bone around the implants.METHODS：Six healthy adult Beagle dogs were randomly divided into experimental and control groups.The second and fourth premolar totally 24 tooth positions in bilateral mandibular from each dog were treated with immediate implant surgery at 1,29,43 and 50 days.Alendronate was local injected around the implant twice a week in the experimental group,but in the control group alendronate was instead by normal saline.RESULTS AND CONCLUSION：X-ray film showed that implant osseointegration was in good condition at 57 days,and the formation of trabecular bone at 2 weeks around the implant in the experimental group was significantly earlier than that in the control group.It is indicated that alendronate can promote the early formation of trabecular,thus affecting the bone remodeling to increase the osseointegration at non-load period around the implants.

关 键 词：阿伦膦酸钠 骨结合 种植体周 非负荷期 二膦酸盐 

分 类 号：R318[医药卫生—生物医学工程]