肥胖、耐力运动对单纯性肥胖少年儿童免疫功能的影响  

Effect of Obesity and Endurance Training on Immune Function in Simple Obese Children

作　　者：叶超群[1] 康玉华[1] 杨俊卿[1] 

机构地区：[1]北京体育师范学院保健与康复系,北京100088

出　　处：《中国运动医学杂志》2000年第1期45-48,共4页Chinese Journal of Sports Medicine

摘　　要：对 2 1名单纯性肥胖少年儿童及 16名正常健康少年儿童的部分免疫指标进行了检测 (T淋巴细胞亚群采用APAAP法 ,NK细胞活性选用LDH释放法 ) ,并对 7名单纯性肥胖少年儿童进行了 10周的耐力训练。结果 :肥胖少儿的CD4+/CD8+、NK活性显著降低 (p <0 0 5 )。CD8+较正常少儿高 ,但无显著性差异 ,白细胞数、中性粒细胞数、淋巴细胞数、CD3+、CD4+、CD16 +、CD56 +两组接近 ;10周耐力训练后 ,肥胖少年儿童的CD4+/CD8+、NK活性显著提高 (p <0 0 5 ) ,CD4+有所提高 ,CD8+有所下降 ,但无显著性差异 ;白细胞数、中性粒细胞数、淋巴细胞数、CD3+、CD16 +、CD56 +无显著性改变。结果表明 :单纯性肥胖少年儿童的免疫功能受损 ,耐力运动能改善肥胖少年儿童的免疫功能。提示单纯性肥胖少年儿童的免疫功能受损与体脂的改变和血脂质代谢紊乱有关。Althoughthesimpleobesechildrenhavebeenreportedtohaveahigherincidenceofinfections ,theirimmunocompetenceremains unclear Thisstudywastoobservewhetherobesityandendurancetrainingaffectimmunefunctioninthesimpleobesechildren The numberofleukocyte,neutrocyte ,lymphocyte ,lymphocytesubsetsandnaturalkillercellactivityweremeasuredandthebloodlipid ,in cludingTC ,TG ,HDL ,LDL ,ApoAI,ApoBwerealsoinvestigatedin 2 1simpleobese ( 5 4± 2 67%bodyfat)and 16non -obese ( 2 0 88± 1 4 0 %bodyfat)healthychildren Sevensimpleobesechildrencarriedoutanexerciseprogram :80— 110min/d ,3 - 4d/ w ,for10w ,withwalking ,jogging ,swimming ,game,etc ,exerciseintensityat( 5 0 - 70 % )×PHR Theresultsshowedthattheimmune functioninobesechildrenwasinhibited :CD4+/CD8+ratioandNKcellactivitydecreasedsignificantlyVSthecontrolgroup (p < 0 0 5 )andthatendurancetrainingmayimprovetheimpairedimmunefunctioninsimpleobesechildren :CD4+/CD8+ratioandNK cellactivityincreasedsignificantlyafter 10 -weekendurancetraining Theresultssuggestedthatthesimpleobesechildrenhaveim munefunctionimpairment,whichimprovedafterendurancetraining

关 键 词：肥胖 免疫功能 耐力运动 儿童 

分 类 号：R723.14[医药卫生—儿科]