碱性条件下4(3H)-喹唑啉酮的一锅合成  

One-Pot Synthesis of 4(3H)-Quinazolinone under Base Condition

作　　者：刘长娥[1] 于琪瑶[2] 唐健红[1,3] 李加荣[1] 

机构地区：[1]北京理工大学化工与环境学院,北京100081 [2]北京理工大学化学学院,北京100081 [3]华侨大学化工学院,厦门362021

出　　处：《有机化学》2012年第3期532-537,共6页Chinese Journal of Organic Chemistry

摘　　要：研究了一种碱性条件下由邻氨基芳香腈1与醛2一锅合成4(3H)-喹唑啉酮3的新方法.反应经由亲核加成、分子内的Pinner关环、Dimroth重排和氧化脱氢串联转化而成.产物结构经1H NMR,13C NMR,IR和元素分析确证.A series of 4（3H）-quinazolinones 3 were obtained from the one-pot synthesis of available substituted aromatic o-aminonitriles 1 with aldehydes 2 in the present of base.This tandem transformation was included in addition,intramolecular Pinner reaction,Dimroth rearrangement and oxidative dehydrogenation.The structures of products were characterized by 1H NMR,13C NMR,IR spectra and elemental analysis.

关 键 词：一锅合成 邻氨基芳香腈 醛 碱催化 4(3H)-喹唑啉酮 

分 类 号：O626[理学—有机化学]