无溶剂条件下简单、有效地合成1,6-二氢嘧啶-6-酮衍生物  

A Facile and Efficient Synthesis of 1,6-Dihydro-6-oxo-pyrimidine Derivatives under Solvent-Free Conditions

作　　者：刘丽华[1] 殷姗[2] 夏盛[2] 蔡佩君[1] 荣良策[1,2] 

机构地区：[1]中国矿业大学化工学院,徐州221008 [2]徐州师范大学化学化工学院,徐州221116

出　　处：《有机化学》2012年第3期612-615,共4页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基础研究基金(No.08KJB150017);徐州师范大学科研平台(No.10XLS02)资助项目~~

摘　　要：以芳醛、氰乙酸乙酯和碳酸胍为原料,氢氧化钠-碳酸钾为催化剂,在无溶剂条件下70℃反应有效地合成了1,6-二氢嘧啶-6-酮衍生物,本方法具有反应时间短、条件温和、处理简单和环境友好等优点.通过红外、核磁、高分辨质谱和晶体的X衍射确定产物的结构.An efficient and facile synthesis of 2-amino-1,6-dihydro-6-oxo-pyrimidine derivatives via reaction of aromatic aldehydes,ethyl 2-cyanoacetate and guanidine carbonate by using NaOH and K2CO3 as catalyst under solvent-free conditions at about 70 ℃ is reported.This protocol has the advantages of shorter time,mild conditions,easy work-up and environmental friendliness.The products were identified by IR,1H NMR and HRMS techniques,and that of 4e was additionally confirmed by X-ray diffraction analysis.

关 键 词：1 6-二氢-6-嘧啶酮 杂环化合物 无溶剂反应 

分 类 号：O626.41[理学—有机化学]