MoO_3/Al_2O_3催化氧化选择性合成亚砜  

Selective Synthesis of Sulfoxides by Oxidation Using MoO_3/Al_2O_3 as Catalyst

作　　者：孙莉[1] 杨振平[1] 郭罕奇[1] 裴文[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310014

出　　处：《有机化学》2012年第3期624-626,共3页Chinese Journal of Organic Chemistry

摘　　要：采用浸渍法制备了不同负载量的MoO3/Al2O3催化剂,讨论了MoO3,Al2O3和MoO3/Al2O3负载的催化剂作用下,利用H2O2进行硫醚氧化制亚砜的反应.结果显示MoO3/Al2O3催化剂负载量为20%时催化活性最高,原料转化率达100%,且没有副产物生成.将该方法应用到兰索拉唑前体的氧化反应中,收率达到80%.催化剂重复使用6次不失活.MoO3/Al2O3 solid base catalysts were prepared by impregnation method and the catalytic activity of MoO3,Al2O3 and MoO3/Al2O3 were investigated in the oxidation reaction of sulfoether to sulfoxide using H2O2 as oxidant.The result indicated that the conversion was 100% and no by-product produced when the catalyst of MoO3/Al2O3 loaded 20% of MoO3.Then,the intermediate of lansoprazole was oxidated by using the same method to get the corresponding lansoprazole in the yield of 80%.The catalyst could be used 6 times without deactivity.

关 键 词：MoO3/Al2O3 亚砜 兰索拉唑 氧化反应 

分 类 号：TQ227.3[化学工程—有机化工]