宫颈糜烂患者单纯疱疹病毒Ⅱ型感染情况分析  

Analysis of Herpes Simplex VirusⅡ in Cervical Specimens from Patients with Cervicitis

作　　者：张丽[1] 杨慧兰[2] 刘仲荣[2] 樊建勇[2] 毕建军[2] 

机构地区：[1]南方医科大学研究生院,广东广州510515 [2]广州军区广州总医院皮肤科,广东广州510010

出　　处：《中国皮肤性病学杂志》2012年第4期319-320,325,共3页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金(30972666)

摘　　要：目的探讨宫颈糜烂患者单纯疱疹病毒(HSV-Ⅱ)感染情况。方法用实时荧光定量PCR法对212例受试者宫颈棉拭子中HSV-Ⅱ进行检测。结果 162例宫颈糜烂患者中,HSV-Ⅱ阳性率为29.01%(47/162),50例正常对照组中,HSV-Ⅱ阳性率为10.00%(5/50),两组差异有统计学意义(P<0.05)。Ⅰ,Ⅱ和Ⅲ度宫颈糜烂患者HSV-Ⅱ阳性率分别为19.64%(11/56),27.78%(15/54)和40.38%(21/52),提示宫颈糜烂程度与HSV-Ⅱ的阳性率呈正相关(r=0.186,P<0.05)。结论 HSV-Ⅱ感染与宫颈糜烂密切相关,且随宫颈糜烂程度的增加,HSV-Ⅱ感染率增加。应加强对宫颈糜烂患者HSV-Ⅱ的检测。Objective To explore the proportion of herpes simplex virus Ⅱ （HSV-Ⅱ ） in cervical specimens from pa- tients with cervicitis. Methods HSV -Ⅱ in cervical specimens from 212 female patients was detected by QT-PCR. Results Forty-seven cases were positive（29.01%） of the 162 patients with cervicitis and 5 （10.00%） of the 50 controls were positive for HSV-Ⅱ,there were statistically significant differences in detection rate between cervicitis and control group （P 〈 0.05）. The infection rate of HSV were 19.64% （11/ 56）,27.78 %（15/54）and 40.38%（21/52）with cervicitis degree Ⅰ, Ⅱ,and Ⅲ, cervicitis degree and the positive rate of HSV- Ⅱ were positively correlated （r=0.186,P 〈 0.05）. Conclusion The results indicate that HSV- Ⅱ infection is closely related to cervicitis. The infection rate of HSV- Ⅱ increased with the increment of cervicitis degree; HSV- Ⅱ should be detected in patient with cervical erosion.

关 键 词：实时荧光定量PCR 单纯疱疹病毒 宫颈糜烂 

分 类 号：R711.32[医药卫生—妇产科学]