肝郁脾虚证与乳腺增生病的相关性探讨  

Discussion on correlation between hyperplasia of mammary glands and syndrome of stagnation of the liver qi with deficiency of the spleen

作　　者：李琳[1] 宋爱莉[1] 

机构地区：[1]山东中医药大学,山东济南250014

出　　处：《山东中医杂志》2000年第1期6-8,共3页Shandong Journal of Traditional Chinese Medicine

摘　　要：临床中发现大多数乳腺增生病患者出现的一系列症状,符合肝郁脾虚证诊断标准;乳腺增生病的基本病机是肝郁犯脾,脾虚运化失权,津液敷布障碍,水湿内停,与气、痰、瘀互阻于乳络所致;中医内治应从疏肝理气、健脾渗湿、养血活血、利尿消肿入手,且注意经前经后用药各有侧重;现代医学认为该类乳腺增生存在着乳腺组织间的水钠潴留等重要病理改变;对其相关性进一步探讨,应从黄体期P、PRL水平,乳腺组织ER、PR分布与含量,微循环与乳房血流动力学,BCL-2蛋白及PCNA表达4个方面寻找特异性微观辨证指标。Most clinical features of hyperplasia of mammary glands(HMG) are found to meet the diagnostic criteria of syndrome of stagnation of liver qi with deficiency of the spleen The pathogenesis of HMG is that stagnated liver qi transfer pathogen to the spleen,causing the fluid retention of the body,companying with qi,phlegm and blood stasis stay in the collateral of breast The treatment are relieving the depressed liver,strengthening the spleen,dispelling body fluid,nourishing and activating the blood circulation In western medicine,this type of HMG is connected with the pathological changes of water and salt metabolic disturbance The P,PRL level of corpus luteum period,content of ER,PR in breast tissue,microcirculation and dynamic blood stream in the breast,and express of BCL 2,PCNA are the important index to study the correlation between them Key words:hyperplasia of mammary glands;stagnation of the liver qi and deficiency of the spleen;correlationcompression), ratio of energy (elastic energy/binding energy) and BFI (brittle fracture index). The critical values of the ER/PC , the ratio of energy and BFI for predicting capping and lamination were 1.5,15% and 0.5 in experiments. The results showed that the paracetamol powder with needle shaped crystal had greater extent of capping and lamination than those of others because it has a typical Mohr body compression behavior and has brittle fracture bonding characte ristics. The extent of capping and lamination may be improved by mixing plastic excipients or being granulated with adhesives in tablets making.

关 键 词：乳腺增生病 肝郁脾虚 相关性 

分 类 号：R271.44[医药卫生—中医妇科学]