包覆ZrO_2的介孔SBA-15涂敷纤维素衍生物手性固定相的制备及手性醇的直接拆分  

Preparation of SBA@ZrO_2 Coated with Cellulose Derivatives and Direct Resolution of Chiral Alcohols by High Performance Liquid Chratogomraphy

作　　者：杜明霞[1] 丁春艳[1] 黄灵利[1] 叶锐[1] 李争光[1] 李文智[1] 

机构地区：[1]聊城大学材料科学与工程学院,山东聊城252059

出　　处：《聊城大学学报（自然科学版）》2012年第1期57-60,65,共5页Journal of Liaocheng University:Natural Science Edition

基　　金：国家自然科学基金资助课题(51072075);聊城大学大学生科技文化创新基金项目(SRT10002CL2)

摘　　要：用碱蒸汽法制备表层纳米氧化锆包覆的介孔SBA-15微球(SBA@ZrO2),并将其作为高效液相色谱柱的填料.将自制的纤维素-三(3,5-二甲基苯基氨基甲酸酯)直接涂敷到SBA@ZrO2核壳复合微球上,作为手性固定相,通过高效液相色谱对十种手性醇进行了直接拆分.研究发现,运用此方法制备介孔微球简单、高效,不仅保持了SBA-15介孔微球颗粒的均匀性、较大的孔径,较高的比表面积、规则的孔道和优良的渗透性等的优点,又具有氧化锆的表面特性;实验发现此手性固定相具有较好的拆分能力,可以对手性醇进行良好的拆分.介孔SBA@ZrO2可以用作高效液相色谱的填料.The SBA@ZrO2 was prepared by the NH3/water vapor-induced internal hydrolysis method for post-synthesis coating of zirconia on the mesopore walls of SBA-15 as supports for high performance liquid chratogomraphy.The support prepared by this method was of larger surface area,lower density,better permeability,less background pressure for chiral separation.SBA@ZrO2 was coated with cellulose tris-（3,5-dimethylphenylcarbamate）（CDMPC） as the chrial stationary phase.Direct optical resolutions of ten racemates were successfully obtained on the chrial stationary phase.It is expected the SBA@ZrO2 as the packing materials have a potential use in separation.

关 键 词：氧化硅@氧化锆 纤维素-三(3 5-二甲基苯基氨基甲酸酯) 手性固定相 高效液相色谱 

分 类 号：TB321[一般工业技术—材料科学与工程]