霉酚酸酯与间断性环磷酰胺静脉冲击疗法治疗弥漫增生型狼疮性肾炎的Meta分析  

Meta-analysis of mycophenolate mofetil versus cyclophosphamide for diffuse proliferative lupus nephritis

作　　者：李静[1] 夏正坤[1] 高远赋[1] 樊忠民[1] 高春林[1] 任献国[1] 

机构地区：[1]南京大学医学院临床学院南京军区南京总医院儿科,210002

出　　处：《国际儿科学杂志》2012年第2期208-211,共4页International Journal of Pediatrics

基　　金：江苏省重点医学人才基金（RC2007115）

摘　　要：目的评价霉酚酸酯（MMF）与间断性环磷酰胺（CTX）静脉冲击疗法治疗弥漫增生型狼疮性肾炎（DPLN）的有效性和安全性。方法检索PubMed、MEDLINE和中国期刊网等数据库，收集MMF与间断性CTX静脉冲击疗法治疗DPLN的随机对照试验14篇。使用RevMan5．0软件分析评价临床总缓解率、复发率、病死率、疱疹的情况。结果患者临床总缓解率，MMF较间断性CTX静脉冲击疗法高（P〈0．05）。而复发率、病死率、疱疹情况，差异无统计学意义（P〉0．05）。结论MMF治疗DPLN的有效性和安全性较间断性CTX静脉冲击疗法为优。Objective To estimate the application of mycophenolate mofetiliMMF） and cyclophospha- mide（CTX） intravenous pulse therapy on diffuse proliferative lupus nephritis （DPLN）. Method PubMed, Medline,EMBASE and CNKI were searched from the establishment of the database. Meta-analysis of 14 comparative studies on MMF and CTX in treatment of DPLN was performed, taking the remission, the relapse, the death of MMF and CTX for DPLN as primary efficacy variable, mean while taking the herpes zoster as safety evaluating indicator. Results MMF was better than CTX in remission rate（P 〈0. 05）. There was no difference between in incidence rate of the relapse, the death and the herpes zoste MMF and CTX for DPLN （ P 〉 0.05 ）. Conclusion MMF was better than CTX on the efficacy and safety in DPLN.

关 键 词：霉酚酸酯 环磷酰胺 弥漫增生型狼疮性肾炎 META分析 

分 类 号：R593.242[医药卫生—内科学]