大黄酸对内毒素激活小胶质细胞的影响  

Effects of 1.8-Dihydroxy-3-carboxy-anthraquinone on LPS-induced microglial activation

作　　者：景浩然[1] 柴丽娟[1] 郭虹[1] 李美娇[1] 刘青青[1] 王少峡[1] 

机构地区：[1]天津中医药大学中医药研究院天津市中药药理学重点实验室教育部方剂学重点实验室,300193

出　　处：《天津中医药大学学报》2012年第1期34-35,共2页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(81001654);天津市卫生局科技基金(2010KZ120)

摘　　要：[目的]旨在观察大黄酸对小胶质细胞细胞株的作用。[方法]培养小胶质细胞细胞株,检测大黄酸对小胶质细胞活力及内毒素(LPS)诱导小胶质细胞一氧化氮(NO)产生的影响。[结果]大黄酸可以在不影响细胞活力的情况下抑制NO在激活小胶质细胞中的产生。[结论]大黄酸可以抑制LPS对小胶质细胞的激活。[Objective] This study examined whether 1.8-Dihydroxy-3-carboxy-anthraquinone, a metabolite from Salvia miltiorrhiza, may exert an anti-inflammatory effect in microglia. [Methods] We examined the effect of 1.8-Dihydroxy-3-carboxy-anthraquinone on cell viability and the production of nitric oxide （NO） induced by LPS treatment in rat primary cultured microglia. [Results] 1.8-Dihydroxy-3-carboxy-anthraquinone could significantly inhibit the production of NO by LPS treatment in rat primary cultured microglia. [Conclusion] 1.8-Dihydroxy-3-carboxy-anthraquinone can suppress microglial activation and this may be a mechanism underlying the neuroprotective activity of it.

关 键 词：大黄酸 小胶质细胞 炎性反应 

分 类 号：R285.5[医药卫生—中药学]