经皮腰椎间盘切除术联合臭氧与联合胶原酶治疗腰椎间盘突出症的对比研究  

The treatment of lumbar disc herniation:a comparison between percutaneous lumbar diskectomy combined with ozone and percutaneous lumbar diskectomy combined with collagenase

作　　者：钟立明[1,2] 魏欣[1,2] 胡鸿[1,2] 游箭[1,2] 赵晓伟[1,2] 胡孔琼[1,2] 

机构地区：[1]川北医学院第二临床学院 [2]南充市中心医院医学影像科介入医学中心,四川省南充637000

出　　处：《介入放射学杂志》2012年第3期243-245,共3页Journal of Interventional Radiology

摘　　要：目的比较经皮腰椎间盘切除术(PLD)联合臭氧与联合胶原酶治疗腰椎间盘突出症的近期疗效和术后不良事件。方法以PLD联合胶原酶溶解术治疗为对照组(115例),以PLD联合臭氧消融术治疗组为观察组(108例),进行治疗前、后对照研究,纳入随访资料完整者共计223例,观察两组的近期疗效情况和术后不良事件情况。结果观察108例优良率为85.18%(92/108),术后不良事件发生率为5.56%;对照组115例优良率为80.00%(92/115),术后不良事件发生率为13.04%;两组近期疗效的差异无统计学意义(Pearson Chi-Square,值为1.038,P=0.308),两组术后不良事件的差异无统计学意义(Pearson Chi-Square值为3.661,P=0.056);PLD观察组末发生椎间盘感染。结论两组疗效无明显差异,为保持椎间盘内长期的减压效果和减少术后不良事件的发生率,PLD联合臭氧消融术是具有互补性的有效治疗方法。Objective To evaluate the short-term curative effect and the incidence of postoperative adverse events of percutaneous lumbar diskectomy （PLD） combined with ozone or PLD combined with collagenase in treating lumbar disk herniation. Methods A total of 223 patients with lumbar disk herniation were enrolled in this study. Patients in the study group （n = 108） were treated with PLD combined with ozone, while patients in the control group （n = 115） were treated with PLD combined with collagenase. The short-term effectiveness and the incidence of postoperative adverse events were documented. The results were analyzed and compared between the two groups. Results In the study group, the excellent and good therapeutic results were achieved in 85.18% of the patients （n = 92） and the occurrence of adverse events was 5.56%, while in the control group, the excellent and good therapeutic results were achieved in 80.00% of the patients （n = 92） and the occurrence of adverse events was 13.04%. No significant difference in the short-term effectiveness existed between the two groups （Pearson Chi-Square = 1.038, P = 0.308）. And the difference in the occurrence of postoperative adverse events was not significant between the two groups （Pearson Chi-Square = 3.661, P = 0.056）. No disc infection occurred in the study group. Conclusion The short-term curative effect of PLD combined with ozone is not significantly different from that of PLD combined with collagenase. In order to maintain decompression within the disc for a long period and to reduce the incidence of postoperative adverse events PLD combined with ozone ablation is an effective complementary treatment.

关 键 词：腰椎间盘突出症 经皮腰椎间盘切除术 臭氧 胶原酶 

分 类 号：R681.53[医药卫生—骨科学]