涤纶/左旋聚乳酸静电纺人造小血管的性能  

Property research of electrospun polyester/poly(L-lactic acid) small diameter vascular graft

作　　者：杜雪子[1] 李毓陵[1] 陈志龙[2] 严懿嘉[2] 

机构地区：[1]东华大学纺织学院纺织面料技术教育部重点实验室,上海市201620 [2]东华大学化工与生物工程学院,上海市201620

出　　处：《中国组织工程研究》2012年第8期1377-1381,共5页Chinese Journal of Tissue Engineering Research

基　　金：国家"111"计划项目资助(B07024)~~

摘　　要：背景:小口径人造血管常用生物材料左旋聚乳酸,在体内的降解速率不能与损伤缺失小血管的组织细胞修复速率相匹配,且绝对力学强度不够高,不能满足病变血管的修复要求。目的:观察不同质量混纺比的涤纶/左旋聚乳酸静电纺人造小血管生物力学性能及生物相容性。方法:将涤纶和左旋聚乳酸在质量配比为10∶0,7∶3,5∶5,3∶7,0∶10条件下,通过双头静电纺丝制备纳米纤维人造小血管。结果与结论:涤纶/左旋聚乳酸静电纺混纺结构在纳米级条件下,涤纶与左旋聚乳酸不会发生化学反应,维持各自特性,其力学性能较纯左旋聚乳酸有较大改善,且具备孔隙率高,透水率低的特点,既利于细胞生长,又不会导致液体大量渗透。质量混纺比为5∶5时制备的涤纶和左旋聚乳酸人造血管各方面性能较优,其生物相容性可通过调节工艺参数细化纤维来改善。BACKGROUND： At present, poly（L-lactic acid） （PLLA） is always used as the biological material of vascular graft. However, decomposition rate of PLLA in the body cannot match with cells growing rate of the diseased small blood vessel, and absolute mechanical strength of PLLA is not quite high, which cannot meet the requirements of the diseased blood vessel. OBJECTIVE： To explore the biomechanical performance and biocompatibility of electrospun polyester/PLLA small diameter vascular grafts at different matching ratio. METHODS： Small diameter vascular grafts were produced with polyester and PLLA in the mass ratio of 10：0, 7：3, 5：5, 3：7, 0：10, using double injection pumps in the opposite directions. RESULTS AND CONCLUSION： In the nanoscale conditions, polyester and PLLA with mixed structure made by the injection pumps in the opposite directions could produce chemical reaction, maintaining their characteristics. Compared with pure PLLA, the mixed structure had greatly improved the mechanical performance with the high porosity and low water permeability that was good for the growth of cells, and could not lead to a liquid penetration. In the mixed conditions, the biocompatibility of the scaffold could be improved by adjusting the process parameters to refine fibers. The vascular graft （mass ratio 5：5） had full advantage of material properties.

关 键 词：涤纶 静电纺 左旋聚乳酸 小口径人造血管 混纺结构 生物相容性 

分 类 号：R318[医药卫生—生物医学工程]