可控释淫羊藿苷的羟基磷灰石/壳聚糖缓释支架修复骨缺损  

Controlled-release icariin loaded-hydroxyapatite/chitosan scaffold for repair of bone defects

作　　者：郑军[1] 徐小燕[1] 汤伟忠[1] 周恩元[1] 年华[1] 

机构地区：[1]上海中医药大学附属岳阳医院骨科,上海市200437

出　　处：《中国组织工程研究》2012年第8期1455-1458,共4页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81072958)~~

摘　　要：背景:如何将中药有效活性化合物通过生物支架材料的缓释作用更好的应用于骨科临床尚需大量的研究。目的:通过文献检索和综合分析,客观评估中药活性成分复合淫羊藿苷的缓释支架在骨修复领域应用的可行性。方法:分别用英文检索词"bone defect,icariin,release bracket,chitosan,hydroxyapatite";中文检索词"骨缺损,淫羊藿苷,壳聚糖,羟基磷灰石,缓释支架"检索CNKI及PubMed数据库1995-01/2010-12相关文章,纳入和研究目的相关的文章进行分析综述。结果与结论:共纳入相关文献24篇,已有研究表明中药淫羊藿苷可促进成骨细胞的生成,抑制骨吸收。而纳米羟基磷灰石-壳聚糖复合支架具有良好的理化性质和细胞相容性,可以应用于组织工程骨的构建。因此在进一步完善纳米级晶体合成工艺的基础上,对淫羊藿苷的释放速度和释放模式加以控制,达到持续、稳定的药物缓释是可行的。BACKGROUND： Much more studies are in need to understand how to apply the effective bio-active compounds of Traditional Chinese Medicine to orthopaedics clinical practices through the controlled release biological brackets. OBJECTIVE： To objectively evaluate the feasibility of applying the effective bio-active compounds of Traditional Chinese Medicine composite with icariin-release brackets to bone repair by literature search and comprehensive analysis. METHODS： A computer-based online search of related articles published from January 1995 to December 2010 was performed in CNKI database and PubMed database using the key words of ＂bone defect, icariin, release bracket, chitosan, hydroxyapatite＂ in Chinese and in English, respectively. Articles related to research purposes were involved to summarize. RESULTS AND CONCLUSION： Totally 24 literatures were involved. Studies have shown that icariin medicine can promote the formation of osteoblasts and inhibit bone resorption. The nano hydroxyapatite-chitosan composite scaffolds have the good physical and chemical properties and biocompatibility, and can be used to build tissue engineered bone. Therefore, it is feasible to control the release rate and release pattern of icariin in order to achieve sustained and stable drug delivery based on the further improved synthesis of nano-crystals.

关 键 词：淫羊藿苷 骨缺损 壳聚糖 羟基磷灰石 缓释支架 

分 类 号：R318[医药卫生—生物医学工程]