61例不完全性川崎病与微小病毒B19感染  

The relationship between human parvovirusB19 infection and 61 cases incomplete Kawasaki disease

作　　者：郑岩[1] 

机构地区：[1]长春市儿童医院,吉林长春130051

出　　处：《中国实验诊断学》2012年第3期439-441,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨不完全性川崎病与微小病毒B19(HPVB19)感染相关性。方法应用巢式PCR法对166例典型川崎病(KD)(观察组)及61例不完全性川崎病(对照组)进行B19-DNA检测。对观察组与对照组HPVB19-DNA检测阳性的与阴性的两组中应用心脏彩超检测冠状动脉内径值进行比较。结果观察组(典型川崎病)B19-DNA阳性检出率为27.4%(45/166),对照组(不完全性川崎病)B19-DNA阳性检出率检为47.5%(29/61),两组比较有显著差别(P<0.01)。观察组(典型川崎病)与对照组(不完全性川崎病)HPVB19-DNA检测阳性的两组中,心脏彩超冠状动脉内径值比较有显著差异(P<0.01)。结论微小病毒B19与不完全性川崎病(KD)相关,并且微小病毒B19感染造成冠状动脉病变比较严重。Objective To studay the relationship between human parvovirusB19 infection and incomplete Kawasaki disease.Methods 166 cases with a diagnosis of KD in children,s hospital as observing group,61 cases with a diagnosis of incomplete KD as control group.using the nested-PCR detect microvirus B19-DNA in plasma.In the observing group,we compared the data of bore in coronary artery between the observing group and the control group.Results Of the observing group,the positive rate forB19-DNA is 27.4%（45/166）,of the control group,the positive rate forB19-DNA is 47.5%（29/61）.There are significant difference between the two groups（P〈0.01）.Both the observing group and the control group,the data of bore in coronary artery of the HPVB19-DNA positive,is significant（P〈0.01）.Conclusion HPVB19 play an important role in incomplete KD,The coronary complications in incomplete KD infected HPVB19 is more serious.

关 键 词：不完全性川崎病 微小病毒B19感染 巢式聚合酶链反应 

分 类 号：R725.4[医药卫生—儿科]