血清胱抑素C和β_2-微球蛋白在糖尿病肾病诊断中的临床意义  

Diabetic nephropathy(DN) Diagnosis Based on Quantitative Measurements of Serum Cys-C and β_2-MG

作　　者：谢能轩 熊志泉 郑丽梅 钱康 

机构地区：[1]赣州市中医院,江西赣州341000

出　　处：《中国实验诊断学》2012年第3期441-443,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨血清中Cys-C、β2-MG浓度在DN诊断中的临床意义。方法以162例2型糖尿病患者为对象,包括正常蛋白尿组(Ⅰ组)61例,早期DN组(Ⅱ组)48例和蛋白尿组(Ⅲ组)53例,采用免疫比浊法测定血清中Cys-C、β2-MG浓度。结果健康对照组和糖尿病I组中Cys-C、β2-MG含量差异不显著,但它们均显著低于糖尿病Ⅱ组和Ⅲ组(P<0.05)。糖尿病III组的Cys-C、β2-MG浓度均显著高于其它各组(P<0.05)。将血清Cys-C、β2-MG单项检测结果用于DN临床诊断时,ROC曲线面积分别为0.978(0.956～1.000)和0.871(0.942～1.000),Youden指数分别为1.952和1.867。结论血清中Cys-C、β2-MG均可用于DN疾病的临床诊断,但Cys-C优于β2-MG。Objective To evaluate the diagnosis value of serum Cys-C and β2-MG levels in diabetic nephropathy（DN）.Methods The turbidimetric immunoassay method was adopted to detect the serum Cys-C and β2-MG levels in 162 type 2 diabetic patients,which contain 61 cases without urinary albumin excretion（group Ⅰ）,48 cases with low urinary albumin concentration（group Ⅱ）,and 53 DN patients（group Ⅲ）.Results There were no significant differences for the serum Cys-C and β2-MG levels between health control group and group I;however,they were significantly lower than that in both group Ⅱ and group Ⅲ（P〈0.05）.The highest serum Cys-C and β2-MG levels were observed in group Ⅲ,which significantly differed with other groups（P〈0.05）.When the two serum biomarkers were used for DN diagnosis,the area under ROC curve were 0.978（0.956-1.000） for Cys-C and 0.871（0.942-1.000） for β2-MG,which combined with the Youden index of 1.952 and 1.867,respectively.Conclusion The serum levels of Cys-C and β2-MG could be employed as biomarkers in the diagnosis of DN.However,the diagnosis power was relatively higher for Cys-C than β2-MG.

关 键 词：糖尿病肾病 CYS-C Β2-MG 分子标志物 

分 类 号：R587.2[医药卫生—内分泌]