心肌标志物的床边检测技术在急性心肌梗死患者中的应用价值  

The application value of detecting cardiac markers by POCT in AMI

作　　者：方捷[1] 吴飞[1] 秦保东[1] 仲人前[1] 

机构地区：[1]第二军医大学附属长征医院实验诊断科,上海200003

出　　处：《中国实验诊断学》2012年第3期444-447,共4页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨心肌标志物的床边检测技术(POCT)在急性心肌梗死患者中的应用价值。方法选取60例急性心肌梗死患者和30例健康人,用POCT仪器分别在治疗前、治疗后12小时、治疗后24小时测定AMI患者血中Myo、cT-nI、Hs-CRP、NT-proBNP含量。结果 AMI患者治疗前各心肌标志物水平显著高于对照组,差异具有统计学意义(P<0.05),治疗后不同时间段浓度呈明显下降趋势,表明治疗有效(P<0.05),cTnI例外,而且随着治疗时间的增加,Myo、Hs-CRP、NT-proBNP的诊断敏感性也随之下降。结论应用POCT技术检测AMI患者各项心肌标志物能快速、准确地为临床医师提供诊断报告,以便及早制定合适的治疗方案,相比传统CLT具有时间和经济上的优势。Objective To investigate the diagnostic value of POCT in patients with acute myocardial infarction（AMI）.Methods AMI patients group（n=60） and control group（n=30） were selected,then we detected the concentration of Myo,cTnI,Hs-CRP and NT-proBNP by POCT apparatus in sera before treatment or 12 h and 24 h after treatment.Results The levels of myocardium markers in patients are higher than in controls significantly（P〈0.05）,there was a downward tendency in concentration of above items at different time,which indicated the treatment was effective.However,the level of cTnI has not showed the same trend.The diagnostic sensitivity of Myo,Hs-CRP and NT-proBNP decreased gradually with the extension of treatment time.Conclusion The detection of myocardium markers by POCT could offer the laboratory results more quickly and more accurately for clinical diagnosis in AMI,which also supply the evidence for treatment.Compared with the traditionary CLT,this mothod has more advantages with time and economic.

关 键 词：急性心肌梗死 床边检测技术 心肌标志物 

分 类 号：R542.22[医药卫生—心血管疾病]