CD4^+ CD25^+调节性T细胞与IL-17在梅毒血清固定患者外周血中的表达及意义  

Expression and Clinical Significance of CD4^+ CD25^+ Regulatory T Cells and Interleukin-17 in Peripheral Blood of Patients with Sero-resistance of Syphilis

作　　者：孙澍彬[1] 欧健梅 庄慈妹 

机构地区：[1]东莞市石龙人民医院,广东东莞523021

出　　处：《皮肤性病诊疗学杂志》2012年第1期19-21,共3页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：目的:观察梅毒血清固定患者外周血中CD4+CD25+调节性T细胞和IL-17的表达及意义。方法:采用三色流式细胞术及免疫酶联吸附法测定18例梅毒血清固定患者和18例对照者外周血中CD4+CD25+调节性T细胞和IL-17的表达水平。结果:梅毒血清固定患者外周血CD4+CD25+调节性T细胞的含量明显高于对照组(t=6.29,P<0.01);IL-17的含量与对照组比较差异无统计学意义(t=-1.68,P=0.102)。结论:CD4+CD25+调节性T细胞表达水平增高造成的免疫抑制可能与梅毒血清固定有关;IL-17的表达水平可能与梅毒血清固定无关。Objective：To observate the expression and significance of CD4＋CD25＋ regulatory T cells and interleukin-17（IL-17） in patients with sero-resistance of syphilis. Methods：CD4＋CD25＋ regulatory T cells and IL-17 in peripheral blood of 18 patients with sero-resistance of syphilis and 18 normal controls were examined by flow cytometry and enzyme-linked immunosorbent assay（ELISA）. Results：The content of CD4＋CD25＋ regulatory T cells was higher in patients with sero-resistance of syphilis than that in normal controls（t=6.29,P0.01）,but the serum level of IL-17 were similar for the two groups of subjects（t=-1.68,P=0.102）. Conclusion：The data suggests an important role of CD4＋CD25＋ regulatory T cells in the pathogenesis of sero-resistance of syphilis.

关 键 词：梅毒 CD4+ CD25+调节性T细胞 白细胞介素17 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]