瑞舒伐他汀对poloxamer407诱导的小鼠高血脂模型血脂水平的影响  

Effects of rosuvastatin on poloxamer 407-induced hyperlipidemia model mice

作　　者：李红涛[1] 张婷婷[2] 马波[1] 王晓东[1] 李春进[1] 包春艳[1] 吴书元[1] 杨涛[1] 宋光明[2] 

机构地区：[1]武警天津市总队医院内科,天津300162 [2]武警医学院药理学教研室,天津300162

出　　处：《世界临床药物》2012年第3期156-159,共4页World Clinical Drug

摘　　要：目的观察瑞舒伐他汀对poloxamer 407(P-407)诱导的小鼠高血脂模型血脂水平的影响。方法小鼠于腹腔注射P-407前先以瑞舒伐他汀(2或10 mg/kg)连续灌胃,并于腹腔注射P-407(0.3 g/kg)后3 h再次灌胃瑞舒伐他汀。以注射P-407前及注射后第3、4、24及48 h血甘油三酯和胆固醇水平评价瑞舒伐他汀的疗效,同时观察造模后24 h高密度脂蛋白-胆固醇水平。结果瑞舒伐他汀组血清甘油三酯和胆固醇水平减低,具有显著的量效关系,且作用可持续至造模后的48 h。瑞舒伐他汀组小鼠造模后24 h血清高密度脂蛋白-胆固醇水平显著升高(P<0.05)。结论瑞舒伐他汀可有效降低P-407诱导的高血脂模型小鼠的血脂水平。Objective To investigate the effects of rosuvastatin on poloxamer 407-induced hyperlipidemic model mice. Methods The test mice were administered orally with rosuvastatin （2 or 10 mg/kg） for 3 days, then poloxamer 407 （0.3 g/ kg） was intraperitoneally administered, after 3 hours mice were continue to administered rosuvastatin orally. The value of blood triacylglycerol （TG） and cholesterol （CHO） were measured at 0, 3, 4, 24 and 48 h after the poloxamer 407 injection, and the blood HDL-CHO level of time 24 h were measured. Results Poloxamer-407 injection caused hyperlipidemia in the mice. The levels of blood triacylglycerol and cholesterol were decreased, and that of blood HDL-CHO was increased dose-dependently in the group of rosuvastatin. Conclusion Rosuvastatin is an effective hypolipidemic agent for poloxamer 407-induced hyperlipidemic model mice.

关 键 词：瑞舒伐他汀 poloxamer407 高血脂 

分 类 号：R927[医药卫生—药学] R332