卡托普利与小剂量氢氯噻嗪合用治疗高血压疗效观察  

Effectiveness of Captopril in Combination with Low-Dose Hydrochlorothiazide for Systemic Hypertension

作　　者：龚铭[1] 叶向阳[1] 陈锡刚 

机构地区：[1]浙江省瑞安市人民医院内二科,325200

出　　处：《高血压杂志》2000年第1期31-33,共3页Chinese Journal of Hypertension

摘　　要：目的：研究卡托普利与小剂量氢氯噻嗪合用对高血压患者的疗效及对代谢的影响。方法：５０例原发性高血压患者随机分为两组，第１组：单用卡托普利 １２．５ ｍｇ～７５ ｍｇ，每日 ２～３次。第 ２组：卡托普利 １２．５ｍｇ，每日２次，加服氢氯噻嗪１２．５ｍｇ，每日１次，两组治疗时间均为８周，测定治疗前后的基础血压，空腹血糖、血脂、血钾、血尿酸、尿素氮、肌酐，以及治疗前后的２４小时动态血压。结果；卡托普利加小剂量氢氯噻嗪组的总有效率及２４小时动态血压结果均明显优于单用卡托普利组，而且两组治疗前后的代谢指标均无明显改变。结论：卡托普利与小剂量氢氯噻嗪合用治疗高血压较单用卡托普利更有效，而且对代谢无明显影响。Aim: To study the efficacy of captopril (Capoten, Sino-American Shanghai Squibb Pharmaceuticals. Ltd) in combination with low-dose hydrochlorothiazide in hypertension and its effect on metabolism. Methods: Fifty hypertensive patients were randomly divided in two groups. Group 1 :captopril 12. 5 mg-25 mg bid or tid. Group 2 :captopril 12. 5 mg bid plus hydrochlorothiazide 12. 5 mg qd. Both group were treated for 8 weeks. Blood pressure, 24 hour ambulatory blood pressure, metabolic parameters such as fasting blood glucose, blood lipid, blood potassium, urea nitrogen and creatinine were evaluated before and after drug therapy. Results: Total response rate in group 1 was higher than that of group 2 after treatment. No metabolic parameters change was observed in both groups after treatment. Conclusion: Captopril in combination with low-dose hydrochlorothiazide are more effective than captopril alone in the treatment of hypertension. No adverse effect on metabolism was found.

关 键 词：卡托普利 高血压 治疗 氢氯噻嗪 

分 类 号：R544.1[医药卫生—心血管疾病]