关节软骨的自分泌调节  

Autocrine Regulate of Articular Cartilage

作　　者：沈是铭[1] 毛宾尧[1] 

机构地区：[1]宁波市第一医院骨科,宁波市骨科研究所315010

出　　处：《中国矫形外科杂志》2000年第2期173-176,共4页Orthopedic Journal of China

摘　　要：目的 :综述关节软骨自分泌调节的进展。方法 :通过研究在局部环境中 ,关节软骨的主要自分泌因子在细胞分子水平对关节软骨的代谢、修复等方面的调控。结果 :IGF 1,TGF β ,FGFs和BMPs是病损致软骨基质降解时调节关节软骨细胞表型的最重要自分泌因子。PTHrP为软骨自分泌 /旁分泌因子 ,在介调软骨损伤和修复过程中的细胞变化起作用。结论 :关节软骨依靠大量的自分泌因子维持软骨细胞的表型和正常基质的代谢 ,因子间的协同刺激和反馈调节 ,是关节软骨细胞功能的最重要局部调节者。Objective:Synthesize the relevant progressive studies about autocrine regulate of articular cartilage.Methods:Through experiments to study how the main autocrine cytokines regulate the articular cartilage metabolism,repairing and other aspects in regional circumstance Results:IGF-1,TGF-β,FGFs and BMPs are the main autocrine cytokines to regulate chondrocyte phenotype during degradation of matrix for cartilage diseases. PTHrP acts on the repair of injured cartilage as an autocrine/paracrine cytokine. Conclusion: A lot of autocrine cytokines keep the chondrocyte phenotype and normal metabolism of matrix,regulate the chondrocyte functions by their synergetic interactions and feedbacks,so become the most important regional regulators.

关 键 词：关节软骨 软骨细胞 自分泌 调节 

分 类 号：R336[医药卫生—人体生理学]