CRP水平与冠脉药物支架植入术后再狭窄关系的Meta分析  

Association of C-reactive protein level with restenosis after coronary drug elute stenting:a meta-analysis

作　　者：胡榜利[1] 陈斌冠[1] 杨光业[1] 蔡金华[1] 李锐[1] 

机构地区：[1]广西壮族自治区医学科学情报研究所,南宁市530022

出　　处：《微创医学》2012年第1期6-9,共4页Journal of Minimally Invasive Medicine

基　　金：广西科技基础条件平台建设项目(任务号:10-108-18)

摘　　要：目的探讨术前高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平与冠脉药物支架(DES)植入术后再狭窄(ISR)的关系。方法检索维普中文期刊全文数据库、中国生物医学文献数据库、中国知网、PubMed数据库,收集相关原始研究;采用文献质量评价结合Meta分析的方法分析。结果 ISR组患者术前hs-CRP水平显著高于非ISR组的hs-CRP水平,中国人群和随访时间为6个月的亚组分析表明,ISR组患者术前hs-CRP水平显著高于非ISR组的hs-CRP水平。异质性分析显示纳入文献存在显著异质性。偏倚分析表明发表的文章不存在偏倚。结论术前hs-CRP水平与DES植入术后ISR的发生存在显著相关性。Objective To explore the association of baseline high-sensitivity C-reactive protein （hs-CRP） with in stent restenosis （ISR） after coronary drug elute stenting （DES）. Methods PubMed, Vip Chinese Journal Full-text Databank, Chinese Biomedical Database （CBM）, Chinese National Knowledge Infrastructure （CNKI） and PubMed were retrieved for related primary studies. Literature qualification estimation combined Meta analysis were adopted to analysis. Results The baseline level of hs-CRP was significantly higher in ISR group than in no-ISR group. Subgroup analysis for Chinese population and the patients with 6 month follow-up was in agree with the mainly results. Heterogeneity analysis revealed a significantly heterogeneity across the studies. Funnel plots suggested little publication bias. Condusions The baseline level of hs-CRP is significantly associated with the ISR after DES implantation.

关 键 词：C反应蛋白 药物洗脱支架 支架再狭窄 META分析 

分 类 号：R541.4[医药卫生—心血管疾病]