Synthesis and Crystal Structure of 3-(4-Bromobenzyloxy)-6-morpholinopyridazine  

作　　者：张敏 胡方中 吴向阳 仰榴青 

机构地区：[1]School of Chemistry and Chemical Engineering,Jiangsu University [2]State Key Laboratory of Elemento-organic Chemistry,Nankai University [3]School of the Environment,Jiangsu University

出　　处：《Chinese Journal of Structural Chemistry》2012年第3期373-376,共4页结构化学（英文）

基　　金：supported by Jiangsu University (No. 09JDG064)

摘　　要：The title compound 3-（4-bromobenzyloxy）-6-morpholinopyridazine（C15H16BrN3O2） was synthesized,and its crystal structure was studied.It crystallizes in the triclinic system,space group P with a = 8.3408（17）,b = 8.8620（18）,c = 10.832（2） ,α = 108.09（3）,β = 91.28（3）,γ = 100.90（3）°,Dc = 1.562 g/cm3,Z = 2,λ = 0.71073 ,μ（MoKα） = 2.769 mm-1,Mr = 350.22,V = 744.5（3） 3,F（000） = 356,the final R = 0.0522 and wR = 0.1366 for 2016 observed reflections with I 〉 2σ（I）.In the crystal structure,the morpholine ring adopts a chair conformation with O（2） and N（3） atoms at the flap positions-0.656（7） and 0.622（6） out of the mean plane formed by the other four C atoms,respectively.These molecules generate centro-symmetric dimers through intermolecular π-π interaction.The title compound 3-（4-bromobenzyloxy）-6-morpholinopyridazine（C15H16BrN3O2） was synthesized,and its crystal structure was studied.It crystallizes in the triclinic system,space group P with a = 8.3408（17）,b = 8.8620（18）,c = 10.832（2） ,α = 108.09（3）,β = 91.28（3）,γ = 100.90（3）°,Dc = 1.562 g/cm3,Z = 2,λ = 0.71073 ,μ（MoKα） = 2.769 mm-1,Mr = 350.22,V = 744.5（3） 3,F（000） = 356,the final R = 0.0522 and wR = 0.1366 for 2016 observed reflections with I 〉 2σ（I）.In the crystal structure,the morpholine ring adopts a chair conformation with O（2） and N（3） atoms at the flap positions-0.656（7） and 0.622（6） out of the mean plane formed by the other four C atoms,respectively.These molecules generate centro-symmetric dimers through intermolecular π-π interaction.

关 键 词：PYRIDAZINE SYNTHESIS crystal structure 

分 类 号：TQ457.2[化学工程—农药化工]