替米沙坦对高血压患者肾素、血管紧张素Ⅱ、醛固酮的影响和疗效  

The Effect and Efficacy of Telmisartan to Renin,Angiotensin Ⅱ,and Aldosterone of Patients with Hypertension

作　　者：郭一力[1] 杜凤和[1] 龚洪涛[1] 

机构地区：[1]首都医科大学附属北京天坛医院,北京市100050

出　　处：《中国病案》2012年第3期69-70,共2页Chinese Medical Record

摘　　要：目的观察替米沙坦对肾素、血管紧张素Ⅱ、醛固酮的影响和降压疗效。方法选择100例轻中度高血压患者,给予替米沙坦80mg,1次/d,共治疗8周,观察治疗前后血压、心率、肾素、血管紧张素Ⅱ、醛固酮等指标的变化。结果治疗后收缩压和舒张压较治疗前均明显下降(P<0.01),治疗后血管紧张素Ⅱ含量明显增高(P<0.01),而醛固酮含量则较治疗前降低(P<0.01),治疗后肾素活性有明显增高(P<0.05)。结论替米沙坦降压安全有效,且耐受性好,不良反应轻微,是一种比较理想的新型降压药物。Abstract Objective to investigate the effect of telmisartan on renin, angiotensin Ⅱ and aldosterone of patients with hypertension. Methods One hundred patients with mild to moderate hypertension were given telmisartan 80mg/d for eight weeks. The change of blood pressure, heart rate, renin, angiotensinⅡ and aldosterone before and after treatment are observed. Re.stlts After treatment with telmisaxtan , systolic and diastolic pressure of the patients were both obviously lower than basic titer （ P 〈 0.01 ） ; the level of serum angiotensin n was obviously increased （ P 〈 0.01） ; the levels of al- dosterone were significantly decreased（ P 〈0. 01 ）; the level of plasma renin activity was also obviously increased （P 〈 0.05）. Conclusion Telmisartan is a new type of antihypertensive drug for its safe, effective, well tolerance and slight side-effect.

关 键 词：替米沙坦 高血压 肾素 血管紧张素Ⅱ 醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病]