电焊工体内脂质过氧化水平及相关酶活性  

Study on plasmic lipid peroxidation and activities of related enzyme in electric welders

作　　者：翟金霞[1] 胡刚[2] 侯俊[1] 余红娥 张振寰 

机构地区：[1]安徽医科大学卫生系,安徽合肥230032 [2]安徽省职业病防治所,安徽合肥230031 [3]安徽省全椒县武岗医院,安徽全椒239500

出　　处：《疾病控制杂志》2000年第1期72-73,共2页Chinese Journal of Disease Control and Prevention

摘　　要：目的　探讨电焊烟尘对机体脂质过氧化作用的影响。方法　对 39名电焊工及 6 3名对照者的血清 MDA含量及 SOD、GSH- Px活性进行对照。结果　接触组 MDA含量、SOD活性均高于对照组 ,两组间差异有显著性 (P <0 .0 5 ) ;血中 GSH- Px与对照组相比差异无显著性 (P >0 .0 5 ) ;MDA、SOD、GSH- Px在不同工龄组间差异无显著性 (P >0 .0 5 ) ,且与工龄组间相关性较小 (P >0 .0 5 )。结论　电焊烟尘可引起脂质过氧化和 SOD活性的改变。Objective To investigate the mechanism of lipid peroxidation by which welding fumes exert their effect on human body. Methods Plasma level of malonyldialdehyde (MDA), activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH Px) were tested in 39 welders exposed to welding fumes and 63 non exposed control groups. Results The MDA level and SOD activity among exposed welders were significantly higher than that of the non exposed control (P<0.05), but GSH Px activity was not significantly different (P>0.05), while, the MDA level and SOD and GSH Px activities were not related to the length of service. Conclusions Welding fumes could lead to the change in lipid peroxidation and activity of SOD.

关 键 词：电焊工 脂质过氧化 GSH-PX SOD 电焊烟尘 

分 类 号：R135.2[医药卫生—劳动卫生]