环孢菌素A及雷公藤多甙对皮肤角朊细胞株增殖抑制的试验研究  

Research and Experiment of the Inhibiting Ability of Ciclosporin A and Triptergium Wilfordii Hook f Multi - glycoside to the Proliferation of Keratinocyte Lines

作　　者：张倩[1] 陈学荣[1] 殷金珠[2] 

机构地区：[1]北京医科大学第三临床医院皮肤科 [2]北京医科大学免疫教研室,北京100083

出　　处：《中国医药导刊》2000年第1期47-48,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:以皮肤角朊细胞株为模型,探讨免疫抑制剂环孢菌素A及中药雷公藤多甙外用治疗增殖性皮肤病机制。方法:用MTT法研究两药对皮肤角阮细胞株的增殖抑制。结果:环孢菌素A浓度为10^(-4)mg/ml、雷公藤多甙浓度为0.25～0.5μg/ml时,两药开始抑制角阮细胞株增殖,随两药浓度增加,其抑制增殖能力亦增加。Objective; To investigate the mechanism of the external use of the two Immunosuppressive agents - Ci-dosporin A (CSA) and Triptergium Wilfordii Hook f Multi - glycoside (TWG) to proliferatory skin diseases. Method: MTT method is usedto evaluate the inhibition effect of the two agents to the proliferation of keratinocyte lines. Result: when the doses reach to 10-4mg/ml for CSA and 0.25-0.5μg/ml for TWG the inhibition begins. With the increasing of the doses, the inhibiting ability of the two agents also increases.

关 键 词：环孢菌素A 雷公藤多甙 细胞增殖 药理 

分 类 号：R966[医药卫生—药理学]