超声射频信号血管内中膜分析技术在高海拔地区肥胖人群颈部血管功能评价及冠心病风险相关性分析中的应用  

Effect of QIMT and QAS in Evaluating Common Carotid Artery Function of Obese People at High Altitudes and Relative Analysis of Risk Factors of Coronary Heart Disease

作　　者：赵夏夏[1] 王译晗[1] 苗英[1] 宁方艳 王海筠[1] 吉新雁[1] 李亚妮[1] 

机构地区：[1]解放军第一医院特诊科,兰州730030

出　　处：《临床误诊误治》2012年第3期45-47,共3页Clinical Misdiagnosis & Mistherapy

基　　金：兰州军区医药卫生科研基金资助项目(LXH2007018)

摘　　要：目的探讨超声射频信号血管内中膜分析技术(quality intima-media thickness,QIMT)在高海拔地区肥胖人群颈部血管功能评价中的作用及其在冠心病风险相关性分析中的价值。方法选择高海拔地区肥胖者275例(肥胖组)及健康体检者200例(正常组),比较两组体重指数及胆固醇水平,采用超声射频信号QIMT及动脉僵硬度分析技术(quality arteri-al stiffness,QAS)检测两组颈总动脉内膜中层厚度(intima-media thickness,IMT)、扩张性系数、顺应性系数、血管弹性系数、血管硬度参数,并对资料完整的患者进行10年内冠心病风险综合评估。结果两组男性年龄、体重指数、颈总动脉IMT比较差异有统计学意义(P<0.01),总胆固醇、高密度脂蛋白胆固醇(HDL-C)比较差异无统计学意义(P>0.05);两组女性年龄、体重指数、总胆固醇、HDL-C、IMT比较差异均有统计学意义(P<0.05)。肥胖组男性与正常组男性比较,冠心病风险总值、综合评估发病率、相关性风险增高,差异有统计学意义(P<0.05);肥胖组女性与正常组女性比较,冠心病风险总值、综合评估发病率、平均发病率、正常范围的下限、相关性风险均增高,差异有统计学意义(P<0.01)。结论超声射频信号QIMT对肥胖人群IMT及冠心病相对危险性进行评估,具有无创、精确度高、重复性好、操作简便等诸多优点,可作为早期动脉硬化可靠、简便的检查技术。Objective To study the effect of Quality Intima-Media Thickness（QIMT） and Quality Arterial Stiffness（QAS） in evaluating common carotid artery function of obese people at high altitudes and relative analysis of risk factors of coronary heart disease（CHD）.Methods 275 obese people at high altitudes were selected as obese group,and 200 people who underwent healthy examination were selected as normal group.Body weight index and cholesterol of the two groups were detected.QIMT and QAS techniques were used to detect intima-media thickness（IMT）,expansion coefficient,compliance coefficient,vessel flexibility,and vessel stiffness of common carotid artery.Relative analysis of risk factors of coronary heart disease in patients whose clinical data were integrated within the past 10 years was evaluated.Results Compared with the males of normal group,age,body weight index（BMI） and IMT of common carotid artery of the male in obese group showed significant difference（P0.01）,but there was no significant difference in TC,HDL-C（P0.05）.Age,BMI,TC,HDL-C,IMT of females in the two groups showed significant differences（P0.05）.Total risk value,incidence rate of integrated evaluation and correlative risk factors of the males in the two groups showed significant differences（P0.05）,but total risk value,incidence rate of integrated evaluation,the average incidence rate,lower limits of normal indexes and correlative risk factors of the females in the two groups showed significant differences（P0.05）when compared with normal controls.Conclusion QIMT technique has such advantages as real-time,no-trauma,high degree of accuracy,repeatability,and easy operation in evaluating common carotid artery function of obese people and relative analysis of risk factors of CHD.It can be used as an examination method in evaluating early arteriosclerosis in obese people.

关 键 词：肥胖 人群监测 射频信号 冠心病 风险评估 

分 类 号：R541.4[医药卫生—心血管疾病]