高脂血症患者血浆致动脉粥样硬化指数与血栓形成危险因子的相关性研究  

Patients with hyperlipidemia caused by atherosclerosis and thrombosis risk factor index of related research

作　　者：李阳[1] 林泽喜[1] 魏文峰[1] 刘子杰[1] 梁蕊[2] 

机构地区：[1]暨南大学医学院附属顺德妇儿医院内科, 广东省佛山528300 [2]漯河医学高等专科学校第二附属医院内一科

出　　处：《中国基层医药》2012年第6期856-857,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨高脂血症患者血浆致动脉粥样硬化指数（AIP）与血尿酸、血黏度等血栓形成危险因子的关系。方法选取81例高脂血症患者作为研究对象（观察组），另选取同期80例血脂正常人群作为对照组，分别测定两组受试者总胆固醇（Tc）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、低密白脂蛋白（LDL．C）水平及血尿酸、全血黏度、血小板聚集功能及血清C-反应蛋白（CRP）含量，采用多元线性回归分析其与血尿酸、全血黏度、血小板聚集功能及血清CRP含量的关系。结果观察组AIP（2．25±0．18），明显高于对照组的（1．31±0．15）（t=46．71，P〈0．05），且AIP与LDL—C、血尿酸、全血黏度、血小板聚集功能呈正相关（r=0．86、0．85、0．79、0．81、0．77，均P〈0．05），与HDL—C呈负相关（Y=-0．69，P〈0．05）。结论高脂血症患者AIP与血尿酸、血黏度等血栓形成危险因关系密切，可通过早期检测患者AIP以预测血栓形成危险性。Objective To study on the hyperlipidemia patient plasma cause atherosclerosis index and the blood,blood serum uric acid sticks and so on thrombosis risk factors of the relationship. Methods 81 patients with hyperlipidemia patient and 80 cases of normal blood fat crowd as the research object, the two groups were measured blood fat including total bravery solid alcohol （TC）, triglycerides （TG）, high-density lipoprotein cholesterol （hdl-c）, low dense white lipoprotein LDL（ soiid bravery alcohol-C） level,blood uric acid,whole blood viscosity, piatelet aggregation function and serum C-reactive protein（CRP） content, and according to the TG and hdl-c than of both the logarithm of conversion values calculated the two groups of the plasma to atherosclerosis values, and by using the DuoYuan linear regression analysis with the blood acid, whole blood viscosity, platelet aggregation function and serum levels of CRP relationship. Results Observation group AIP（2.25 -＋. 18） was significantly higher（ 1.31 ＋. 15） （t = 46.71, P 〈 0.05 ） , and AlP and LDL-C, uric acid, whole blood viscosity, platelet aggregation was positively correlated （r = 0.86,0.85,0.79,0.81,0.77, all P 〈 0.05 ）, with HDL-C was negatively correlated （ r = -0.69, P 〈 0.05 ）. Conclusion Patients with hyperlipidemia plasma cause atherosclerosis index and patients, such as blood uric acid blood viscosity thrombosis dangerous close by, by early know patients plasma to atherosclerosis index, and monitor patients early blood uric acid and blood viscosity, thrombosis risk factors level,to facilitate accurate assessment of some patients with cardiovascular disease risk, and to guide to take reasonable early intervention measures, reduce cardiovascular events.

关 键 词：动脉粥样硬化 高脂蛋白血症I型 高尿酸血症 血栓形成 

分 类 号：R589.2[医药卫生—内分泌]