川崎病患儿血脂水平与冠状动脉损害的关系研究  

Study on the relationship between the change of serum lipid and pathological change of coronary artery in Kawasaki disease children

作　　者：徐培林 

机构地区：[1]浙江省绍兴县中心医院儿科,312030

出　　处：《中国基层医药》2012年第6期868-869,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨川崎病患儿血脂水平与冠状动脉损害的相关性。方法62例川崎病患儿按照超声心电图显示分为冠状动脉损害组（28例）和非冠状动脉损害组（34例），另选取同期健康体检正常儿童62例作为对照组。比较三组儿童的血脂水平及与冠状动脉损害的关系。结果冠状动脉损害组和非冠状动脉损害组总胆固醇（Tc）水平分别为（5．32±1．74）mmol／L、（5．24±1．67）mmol／L、甘油三酯（TG）分别为（1．67±0．79）mmol／L、（1．74±0．65）mmol／L、低密度脂蛋白胆固醇（LDL-C）分别为（2．87±1．14）mmol／L、（2．72±1．08）mmol／L均明显高于对照组的（3．08±1．28）mmol／L、（1．12±0．56）mmol／L、（2．37±1．06）mmol／L（t=1．70、1．66、1．71，均P〈0．05），高密度脂蛋白胆固醇（HDL—C）分别为（1．03±0．31、1．08±0．57）mmol／L明显低于对照组的（1．65±0．92）mmol／L（t=1．54，P〈0．05）。经过治疗后，非冠状动脉损害组TC、TG、LDL．C水平明显降低（t=1．76、1．88、1．72，均P〈0．05），HDL—C水平明显升高（t=1．90，P〈0．05）；冠状动脉损害组治疗前后血脂水平变化差异均无统计学意义（均P〉0．05）。结论川崎病患儿存在着明显的血脂代谢紊乱，动态监测患儿血脂水平变化可作为川崎病并发冠状动脉损害的早期诊断指标。Objective To explore the relationship between the change of serum lipid and pathological change of coronary artery in Kawasaki disease （KD） children. Methods 62 children with pathological change of coronary artery in KD were divided into pathological of coronary artery group and normal coronary artery group. 62 normal children were selected as control group in the same time. And then the serum lipid status of three groups were compared. Results The TC （ 5.32 ± 1.74 ） mmoL/L, （ 5.24 ± 1.67 ） mmo]/L, TG （ 1.67 ± 0.79 ） mmo]/L, （ 1.74 ± 0. 65 ） mmo]/ L, LDL-C （2.87 ± 1.14 ） mmo]/L, （ 2.72 ± 1.08 ） mmoL/L of KD of the two groups were lower than of the control group （ 3.08 ± 1.28 ） mmoL/L, （ 1.12 ± 0.56） mmol/L, （ 2.37 ± 1.06） mmoL/L （ t = 1.70,1.66,1.71, all P 〈 0.05 ）, and HDL-C（ 1.03 ± 0.31 ） mmoL/L, （ 1.08 ± 0.57 ） mmo]/L higher than that of the control group （ 1.65 ± 0.92 ） mmoL/L（ t = 1.54,P 〈 0.05 ） ; There were no differences between two coronary artery groups. After treated, TC, TG, LDL-C of normal coronary artery group were decreased （ t = 1.76,1.88,1.72, all P 〈 0.05 ）, and HDL-C was increased （ t = 1.90, P 〈 0.05 ）. Conclusion The child ren with KD had dyslipidemia, and the dyslipidemia was recovered slowly. So,it should be an index of early diagnose for KD with coronary artery lesion.

关 键 词：黏膜皮肤淋巴结综合征 冠状动脉疾病 胆固醇 脂蛋白类 

分 类 号：R725.4[医药卫生—儿科]