非体外循环冠状动脉移植术患者术前焦虑研究  

Study of preoperative anxiety of patients undergoing off-pump coronary artery grafting

作　　者：王义军[1] 于海娇[2] 卢家凯[1] 卿恩明[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所麻醉科,北京100029 [2]北京潞河医院麻醉科

出　　处：《心肺血管病杂志》2012年第2期106-108,共3页Journal of Cardiovascular and Pulmonary Diseases

摘　　要：目的:通过非体外循环冠状动脉旁路血管移植术(OPCABG)患者术前焦虑量表和血清学检查,观察OPCABG患者术前焦虑程度,为临床医师提供术前处理参考。方法:随机选取50例拟行择期OPCABG的患者,所有患者自己填写冠状动脉旁路血管移植术术前焦虑量表(ASCABG),并在入院后第二天、术前晚、术日晨和麻醉诱导前即刻抽取静脉血,测定血清皮质醇、血管紧张素Ⅱ、肾上腺素和去甲肾上腺素水平。结果:术前ASCABG评分为42.40±8.37,焦虑相关血清学标志物(皮质醇、血管紧张素Ⅱ、肾上腺素及去甲肾上腺素)结果现实,自入院后第2天患者出现明显焦虑,在术前晚达高峰。与入院后第2天焦虑相关血清学标志物水平比较,其他3个时间点的结果差异具有统计学意义,P<0.05。结论:ASCABG量表对于估测OPCABG患者术前焦虑是可行的,焦虑相关血清学标志物术前变化显著,术前1天晚患者的焦虑水平达高峰。Objective：To provide effective preoperative treatment references for anesthesiologists and cardiac medical staffs by monitoring preoperative anxiety scale and anxiety related serological biomarkers of patients undergoing off-pump coronary artery bapass grafting（OPCABG）.Methods：50 patients undergoing elective OPCABG were randomly included in present study.Patients were requested to independently filled out preoperative anxiety scale for coronary artery bypass grafting patients（ASCABG）.5 mL of venous blood samples were collected for every patients at 4 different time points including the 2nd morning after hopitalization,1st day before operation,the morning of surgery and the moment before induction of general anesthesia.The serum concentration of cortisol（COR）、angiotensin Ⅱ（AⅡ）、epinephrine（E） and norepinephrine（NE） and their correlativigy with ASCABG score were analyzed.Results： The score of ASCABG in recruited patients was 42.40±8.37,The variation trend of serum concentration of anxity related biomarkers demonstrated that the anxity level began to increase at the second day of hospitalization and the peak of anxiety occurred at the night before operation day.Comparing with the results of biomarkers of the second day after hospitalization,the difference of biomarkers at other 3 point presented significant variation（P0.05）.Conclusion： ASCABG is feasible for observation of preoperative anxiety for patients undergoing OPCABG.Variation of serologic anexity related biomarkers are significant,especially in the night before the operation day.The anxiety level of patients are most serious on the last night before operation.

关 键 词：冠状动脉旁路移植术 术前焦虑 冠状动脉搭桥术前焦虑量表 焦虑相关血清学标志物 

分 类 号：R541[医药卫生—心血管疾病]