慢性阻塞性肺疾病急性发作期用药调查  

INVESTIGATION ON THE DRUG - USE CONDITION OF ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

作　　者：李丽[1] 苏军霞[1] 黄小茜[1] 陈海兰[1] 

机构地区：[1]肇庆市第一人民医院,广东肇庆526021

出　　处：《现代医院》2012年第3期74-76,共3页Modern Hospitals

摘　　要：目的调查慢性阻塞性肺疾病急性加重期(AECOPD)患者的用药特点与合理性。方法随机抽取诊断为AECOPD病历100例进行统计分析,参照《慢性阻塞性肺疾病诊治指南》(2007年修订版),评价用药的合理性。结果 100例AECOPD患者中,抗菌药物的使用率为100%,联合使用抗菌药物的比率为72%,病原茵检查及药敏试验送检率88%,使用最多的前三位抗菌药物为阿奇霉素磷酸二氢钠(35%),左氧氟沙星(30%),头孢哌酮舒巴坦(25%),其中特殊品种使用量占抗菌药物使用量的4.56%,抗茵药物使用强度为149DDD;86例患者联合使用了支气管舒张剂,100%患者使用了平喘药,氨茶碱注射液的使用率最高为72%,77%的患者使用了糖皮质激素。结论在调查的AECOPD病历中诊治和药物的使用与指南基本一致,药物品种的选择和使用基本合理,抗茵药物的使用能根据药敏结果及时调整。Objective To investigate the drug -used characteristics and rationality of acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods 100 patients with AECOPD were selected randomly. The rationality of drug - use was evaluated on the basis of the diagnosis and treatment guidance of chronic obstructive pulmonary disease （revised edition 2007）. Results In all 100 patients, the ratio of antibiotics use was 100%, the ratio of combination treatment of antibiotics was 72% and pathogens checking and susceptibility testing were 88%. The top three antibiotics were azithromycin sodium dihydrogen phosphate （35 % ）, levofloxacin （30%） and cefoperazone - sulbactam （25%）. The amount of special varieties use accounted for 4. 56% of antibiotics. The intensity of antibiotics was 149DDD. 86 patients used antibiotics combined with bronchodilator, all patients used anti - asthmatic drugs, the highest using rate of aminophylline injection was up to 72% , and 77% patients used corticosteroids. Condusion In the investigation, the diagnosis and treatment of AECOPD and the drug - used are the same as those of the guideline. The choice of drug variety and use are basically reasonable, the antibiotics use can be adjusted in time according to drug sensitivity.

关 键 词：慢性阻塞性肺疾病 用药调查 抗菌药物 用药指标 

分 类 号：R563.8[医药卫生—呼吸系统]