聚5-羧基吲哚-聚乙交酯可降解导电共聚物的合成与表征  

Synthesis and characterization of electroactive oligomer of poly(indole-5-carboxylic acid)-polyglycolide

作　　者：李英[1,2] 纪小婷[2] 朱英杰[2] 丁彩凤[1,2] 

机构地区：[1]南京工业大学生物与制药工程学院,江苏南京210009 [2]青岛科技大学化学与分子工程学院生态化工教育部重点实验室,山东青岛266042

出　　处：《南京工业大学学报（自然科学版）》2012年第2期100-105,共6页Journal of Nanjing Tech University(Natural Science Edition)

基　　金：山东省教育厅科技计划资助项目(J09LB04)

摘　　要：以N,N'-二环己基碳化二亚胺(DCC)为脱水剂、4-二甲氨基吡啶(DMAP)为催化剂,通过低温缩聚法合成可生物降解并导电的聚5-羧基吲哚(PICA)与聚乙交酯(PGA)的共聚物。合成的产物采用红外光谱仪(FT-IR)、核磁共振氢谱仪(1H NMR)、质谱仪(MS)进行表征。结果表明:产物经25 d降解了41.7%,测得掺杂的共聚物电导率为9.1×10-4S/cm。将乳仓鼠肾细胞(BHK21)黏附于合成的齐聚物膜上,细胞增殖生长效果明显。A novel degradable electroactive conducting oligomer of poly（indole-5-carboxylic acid）（PICA） and hydroxyl-capped polyglycolide（PGA） was synthesized by low-temperature polycondensation with N,N′-dicyclohexylcarbodiimide（DCC） as dehydrating agent and 4-dimethylaminopyridine（DMAP） as catalyst.The properties and the morphology of the oligomer were characterized by Fourier transform infrared spectrum（FT-IR）,nuclear magnetic resonance spectroscopy（1H NMR） and mass spectrometry（MS）.The oligomer degradation reached 41.7% in weight in the first 25 d.The electrical conductivity of the doped oligomer was measured to be 9.1×10-4 S/cm.To investigate the biocompatibility of the oligomer,baby hamster kidney 21 cells（BHK21） were cultured on oligomer film.Results indicated that the oligomer could support BHK21 cell attachment and proliferation.

关 键 词：聚5-羧基吲哚 聚乙交酯 导电聚合物 降解作用 生物相容性 

分 类 号：TQ316.61[化学工程—高聚物工业] O633[理学—高分子化学]