围产期新生儿凝血功能指标变化及其临床意义  

Change of Coagulation Function Indicators in Perinatal Neonate and Its Clinical Significance

作　　者：蒙海强[1] 王玲[1] 莫坚[1] 何海英[1] 

机构地区：[1]广西医科大学第九临床附属医院新生儿科,广西北海536000

出　　处：《医学临床研究》2012年第2期220-222,共3页Journal of Clinical Research

摘　　要：【目的】探讨围产期新生儿凝血功能指标变化及其临床意义。【方法】回顾性分析336例住院围产期新生儿凝血功能指标包括凝血酶原时间（PT）、凝血酶时间（TT）、部分活化凝血活酶时间（APTT）、纤维蛋白原（Fbg）含量、血小板数（PLT）及其他临床资料。【结果】①早产儿凝血功能存在不同程度低下，与足月儿比较差异显著；②按窒息缺氧程度分组，窒息程度越重凝血功能越差；③颅内出血患儿早期凝血功能指标与对照组存在显著差异；颅内出血患儿足月与早产儿组凝血功能指标有显著差异。【结论】动态监测围产期新生儿尤其是早产几凝血功能指标，对颅内出血早期及窒息缺氧程度乃至预后判断有重要临床意义。[Objective] To explore the change of coagulation function indicators in perinatal neonate and its clinical significance. [Methods] The coagulation function indicators including prothrombin time（PT）, throm bin time（TT）, activated partial thromboplastin time（APTT）, fibrinogen（Fbg） content, platelet counts（PLT） and other clinical data in 336 hospitalized perinatal neonates were analyzed retrospectively. [Results]The coag ulation unction in preterm infants was poor at different level, and there was significant difference between pre term infants and fullterm infants. According to the degree of asphyxia and anoxia, all cases were grouped. The severer the asphyxia, the poorer the coagulation function. There was significant difference in the early co agulation function indicators between children with intracranial hemorrhage and control group. There was also significant difference in coagulation indicators between fullterm infants with intracranial hemorrhage and pre term infants. [Conclusion] Dynamic monitoring of coagulation indicators in perinatal neonates, especially pre term infants has important clinical significance for the judgment of early asphyxia and anoxia and the prognosis of intracranial hemorrhage.

关 键 词：血液凝固 婴儿 新生 围产期学 

分 类 号：R714.7[医药卫生—妇产科学]