微量长效达菲林激发方案用于卵巢低反应患者疗效观察  

Prospective Observation on the Efficacy of Microdose Long-acting Diphereline Flare up Provocation Used in Patients with Poor Ovarian Response

作　　者：李颂军 周昱言 陈建林[2] 

机构地区：[1]武警广东边防总队医院生殖中心,广东深圳518000 [2]中南大学湘雅二医院妇产科,湖南长沙410011

出　　处：《医学临床研究》2012年第2期240-243,共4页Journal of Clinical Research

摘　　要：【目的】观察长效达菲林微量激发方案（MF）用于卵巢低反应患者的临床疗效。【方法】选择拟行体外受精或卵细胞浆单精子注射（IVF／ICSI）助孕，既往助孕发生卵巢低反应或预测可能发生低反应的患者，符合纳入标准者共449周期，随机分为两组：A组入选228周期，采用MF方案，完成移植周期183周期；B组入选221周期，采用拮抗剂方案，完成移植周期183周期；前瞻性观察比较两组患者临床结局。【结果】两组患者获卵数，2PN数，优胚数，移植（ET）胚胎数，胚胎种植率，临床妊娠率，流产率、活产率等无显著性差异（P〉0．05），而A组促性腺激素（Gn）天数（7．67土3．12）d和Gn总量（1352．25土730．5）U均小于B组（8．78土1．79）d、（2023．5土624）U，其差异有统计学意义（P〈0．05）。【结论】微量长效达菲林可用于卵巢低反应患者，临床结局与拮抗剂方案相似，而微剂量长效达菲林方案具有Gn天数和Gn用量少、减少患者就诊及注射次数、降低患者经济成本等优点。[Objective]To observe the clinical efficacy of longacting diphereline microdose flare up protocol （MF） used in patients with poor ovarian response. [Methods]The patients who occurred poor ovarian re sponse in previous IVF/ICSI cycle or were predicted to occur poor responder were randomly divided into two groups. A total of 449 cycles were enrolled in the study. The 228 cycles were enrolled in group A which re ceived MF protocol and embryo transfer was completed in 183 cycles. The 221 cycles were enrolled in group B which received antagonist protocol and embryo transfer was completed in 183 cycles. The clinical outcome was observed prospectively. [Results] There was no significant difference in retrieved oocytes, the number of 2PN, high quality embryos, frozen embryos, embryo implantation rate, clinical pregnancy rate, abortion rate and live birth rate＂ between two groups（ P 〉0.05）. The duration and total dose of gonadotropin（Gn） in group A were less than those in group B（7.67±3.12d vs 8.78±1.7 9d, 1352.25±730.5U vs 2023.5±624U）, and there were significant differences（ P 〈0.05）. [Conclusion]Longacting diphereline MF protocol can be used for patients with poor ovarian response. The clinical outcome of longacting MF protocol is similar to antago nist protocol, but it has advantages of less duration and dose of Gn, and can decrease the frequency of visiting the doctor and injection and reduce economic burden of the patients.

关 键 词：卵巢疾病/药物疗法 菲类/投药和剂量 

分 类 号：R711.75[医药卫生—妇产科学]